Safety,effectiveness and quality control of toxic traditional Chinese medicine(TCM) decoction pieces are the core of the inheritance and innovation of TCM.Scientific processing technology is the key to the safe and effective application of toxic TCM decoction pieces.This paper summarized the development process and quality control status of toxic TCM decoction pieces and analyzed the existing problems.The toxicity of toxic TCM decoction pieces could be reduced and its effectiveness be enhanced by processing to ensure their safe and effective clinical application.Therefore,the processing status of toxic TCM decoction pieces was reviewed in this paper.In addition,ancient and modern processing technology of toxic TCM decoction pieces was systematically analyzed and the processing mechanism was preliminarily expounded.On this basis,it was proposed dynamic changes in processing based on the TCM holistic view be studied and material interaction in processing based on the TCM harmonious view be analyzed.This paper provided reference for clarifying the processing mechanism,standardizing processing technology,achieving quality control and guaranteeing clinical safety and effectiveness of toxic TCM decoction pieces.