To explore the mechanism of Shumian Capsules in the treatment of insomnia based on network pharmacology and molecular docking.Methods:The targets of Shumian Capsules were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP) and Swiss Target Prediction.The targets of insomnia were screened out from five databases including GeneCards.STRING was used to construct the protein-protein interaction(PPI) network.DAVID was used for the gene ontology(GO) annotation and Kyoto Encyclopedia of Genes and Genome(KEGG) pathway enrichment.The network of component-target-disease was constructed by Cytoscape 3.5.1.Finally,molecular docking was simulated in Discovery Studio to verify the predicted results.Results:Shumian Capsules acted on 120 targets related to insomnia through 35 active components.The 8 main active components such as quercetin,kaempferol,luteolin,and β-sitosterol acted on 14 key targets including PIK3R1,TNF,CXCL8,AKT1,and IL6 to regulate Toll-like receptor,TNF,and PI3K/AKT signaling pathways.The results of molecular docking showed that all the active components were well docked with the key targets.Conclusion:Shumian Capsules may exert anti-inflammatory effect to relieve insomnia through multiple targets and pathways.