To investigate the influence of Erbu Zhuyu Decoction on the expression of angiopoietin-1(Ang-1) and vascular endothelial growth factor(VEGF) in the endometrium of mice with embryo implantation dysfunction.Methods:Female ICR mice(n=24) were randomly assigned into a blank group,a model group,an Erbu Zhuyu Decoction group,and a progynova group(each n=6).Mifepristone was used to establish the model of embryo implantation dysfunction.The mice in different groups were orally administrated with corresponding agents each day and sacrificed in the afternoon of the 5th day of pregnancy.The morphology of uterus was observed,and the pregnancy rate and average number of embryo implantation sites were calculated.The mRNA levels and protein localization of Ang-1 and VEGF were determined.Results:Compared with the blank group,the modeling decreased the embryo implantation sites(P<0.05) and down-regulated the mRNA levels of Ang-1 and VEGF(P<0.05).Compared with the model group,Erbu Zhuyu Decoction increased the embryo implantation sites(P<0.05) and up-regulated the mRNA levels of Ang-1 and VEGF(P<0.05).Conclusion:Erbu Zhuyu Decoction can up-regulate the mRNA levels of Ang-1 and VEGF to improve the blood supply and promote the receptivity of endometrium,thereby facilitating embryo implantation.