The clinical manifestations of chronic obstructive pulmonary disease(COPD) are mainly persistent respiratory symptoms(cough，expectoration，dyspnea) and irreversible airflow limitation.It is a common and frequently-occurring disease of the respiratory system.Airway mucus hypersecretion，which throughout the pathogenesis，is an important pathophysiological feature in the course of COPD and can affect the condition and prognosis of COPD.Based on the Analysis of its clinical characteristics，it is believed that airway mucus hypersecretion mainly belongs to “phlegm-fluid retention” in traditional Chinese medicine(TCM).The basic pathogenesis of disorder of lung，spleen and kidney，and liver conveyance and dispersion is the important link.Heart qi deficiency and blood stasis are also common pathogenesis.The syndrome differentiation treatment should be based on clearing lung and eliminating phlegm，warming lung and reducing watery phlegm，nourishing qi and invigorating spleen，nourishing kidney to absorb qi.Dispersing liver and regulating qi is supplemented by spleen transportation and nourishing qi，promoting blood circulation and reducing phlegm，combined with syndrome differentiation plus acupuncture and massage，cupping，and acupoint application and other treatment method.This paper explores the syndrome and treatment of COPD airway mucus hypersecretion from the Zangfu-related pathogenesis theory，hoping to get more ideas and methods to enrich the academic connotation of TCM treatment of the disease.