真实世界中丹参川芎嗪注射液治疗脑梗死合并高血压用药方案研究
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国家重点研发计划项目(2018YFC1707400)——“十种中成药大品种和经典名方上市后治疗重大疾病的循证评价及其效应机制的示范研究


Medication Regimen of Danshen Ligustrazine Injection for Cerebral Infarction Combined with Hypertension:A Real-world Study
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    摘要:

    目的:通过对真实世界中丹参川芎嗪注射液联合中西药治疗脑梗死合并高血压的数据分析,探索中西药联合用药的优化方案。方法:从建立的大型电子病历仓库中,提取914例患者信息、843种药物,采用Tabu搜索算法进行数据分析。结果:调控血脂:联用阿托伐他汀钙与硫酸氢氯吡格雷;调控血糖:二甲双胍、脑蛋白水解物与血管保护药,血糖控制不佳联用胰岛素与前列地尔。合并其他症状:卒中后便秘,卒中急性期联用甘油,必要时可联用甘油果糖氯化钠注射液与甘油,恢复期联用甘油与四磨汤;卒中后呃逆:阿司匹林、依达拉奉与甲氧氯普胺;卒中后合并肺部感染,联用喜炎平、灯盏生脉胶囊与连花清瘟,痰多联用鲜竹沥/痰热清与祛痰止咳或清热解毒剂;卒中相关头痛:联合使用地西泮、醒脑静注射液与盐酸氟桂利嗪。结论:本研究中脑梗死合并高血压使用丹参川芎嗪注射液联合的中西药用药方案,符合相关临床指南,可为临床用药提供参考。

    Abstract:

    To analyze the data in the treatment of cerebral infarction combined with hypertension with Danshen Ligustrazine Injection in combination with Chinese and western medicines in the real world and further explore the optimal scheme of combined use of Chinese and western medicines.Methods:The information of 914 patients and 843 drugs were extracted from the electronic medical record database,and the data were analyzed by Tabu search algorithm.Results:Danshen Ligustrazine Injection was used in combination with other medicines for the following conditions.Blood lipid regulation:atorvastatin and clopidogrel.Blood glucose regulation:metformin and cerebroprotein hydrolysate and vascular protectives,combined with insulin and alprostadil in the case of poor blood glucose control.Other symptoms:1) Constipation after stroke:glycerin at acute stage of stroke; glycerin fructose sodium chloride injection and glycerin if necessary; glycerin and Simo Decoction in convalescence.2) Hiccups after stroke:aspirin and edaravone and metoclopramide.3) Pulmonary infection after stroke:Xiyanping Injection and Dengzhanshengmai Capsules and Lianhua Qingwen preparation,combined with Fresh Bamboo Juice/Tanreqing and expectorant antitussives or antipyretic antidotes in the case of excessive phlegm.4) Stroke-related headache:diazepam and Xingnaojing Injection and flunarizine hydrochloride.Conclusion:In this study,the medication regimen involving Danshen Ligustrazine Injection for cerebral infarction combined with hypertension conforms to relevant clinical guidelines and can provide reference for clinical practice.

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胡慧芹,孙粼希,谢雁鸣,高阳,耿洪娇,杨云云.真实世界中丹参川芎嗪注射液治疗脑梗死合并高血压用药方案研究[J].世界中医药,2022,(09).

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  • 收稿日期:2021-04-05
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  • 在线发布日期: 2022-05-30
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