To systematically analyzed the medicinal properties，efficacies，and compatibility characteristics of Psoraleae Fructus(PF) from classical traditional Chinese medicine(TCM) books and ancient and modern prescriptions and explore the clinical medication regularity of PF.Methods:The records of PF in ancient and modern prescriptions were collected from the database of the Nanjing University of Chinese Medicine.The frequency statistical analysis and Apriori algorithm were used to analyze the PF-containing prescriptions，and data mining such as association rule was carried out.Results:PF was an adventive medicinal material from ancient Persia，and was later introduced into China and naturalized as Chinese medicine.The medicinal use of PF was first recorded in Master Lei's Discourse on Medicinal Processing that “it is dry and toxic in nature”.PF was suggested to be processed by stir-frying，salt frying，and wine frying due to its severe dryness.The medicinal properties of PF were similar in records in past dynasties.It was pungent，bitter，and warm in nature，with the effects of warming the kidney，promoting yang，soothing qi，relieving asthma，warming the spleen，and checking diarrhea.PF should not be used with Glycyrrhizae Radix et Rhizoma，iron，Brassica campestris，and blood，and the patients with yin deficiency，excess of fire，dampness，and heat should avoid using it.As revealed by data mining，PF was often used in combination with deficiency-tonifying drugs including Angelicae Sinensis Radix and Eucommiae Cortex for replenishing qi and blood，with interior-warming drugs，such as Cinnamomi Cortex，Aconiti Lateralis Radix Praeparata，and Foeniculi Fructus for warming the kidney and tonifying yang，and with Juglandis Semen for prolonging life，tonifying qi，and replenishing muscles and bones.Conclusion:Based on the data mining and analysis，this study expounded on the origin of PF，processing methods，reasonable compatibility，contraindication，etc.，which is expected to provide a scientific reference for the clinical rational medication of PF and innovation of modern Chinese medicine.