Cancer pain is a common symptom of cancer patients,which seriously destroys their physical and mental health and affects their quality of life.Traditional Chinese medicine can relieve pain,lower the amount of analgesic drugs and reduce adverse reactions,and can significantly improve the quality of life of patients.Professor Hua Baojin pointed out that insufficient healthy qi was the internal cause of cancer pain.Lack of healthy qi resulted in dysfunction of zang-fu organs,deficiency of qi,blood,yin and yang,invasion of pathogenic factors,and blocked meridians,thereby causing pain.In addition,qi stagnation caused by various factors was the inducing factor for the occurrence of cancer pain.It led to the formation of blood stasis,phlegm dampness,heat toxin and other stagnation,blocking meridians and thus causing pain.The cancer toxin due to the long course of disease was the root of recurrent cancer pain.Therefore,regulating qi and removing toxin was one of professor Hua's main methods in the treatment of cancer pain.This paper discussed the application of regulating qi and detoxifying in cancer pain from the aspects of pathogenesis,treatment and prescription.