| 引用本文:胡佳奇1,2，陈顺泰2，葛少侠3，郑红刚1，花宝金1，张葛1.捏筋脉位疗法联合昂丹司琼预防顺铂所致恶心呕吐的临床研究[J].世界中医药,2022,(11):. |
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| 捏筋脉位疗法联合昂丹司琼预防顺铂所致恶心呕吐的临床研究 |
| Clinical Trial of Nie Jinmaiwei Massage Combined with Ondansetron for Chemotherapy-induced Nausea and Vomiting |
| 投稿时间：2022-04-20 |
| DOI：10.3969/j.issn.1673-7202.2022.11.005 |
| 中文关键词: 捏筋脉位 穴位 恶心 呕吐 昂丹司琼 化疗 顺铂 临床研究 |
| English Keywords:Nie Jinmaiwei massage Acupuncture points,Nausea Vomiting Ondansetron Chemotherapy Cisplatin Clinical trial |
| 基金项目:中国中医科学院广安门医院国家中医临床研究示范基地科研专项（2017S399）；中国中医科学院优秀青年科技人才（创新类）培养专项（ZZ13-YQ-023）；中国中医科学院科技创新工程项目（CI2021A01810，CI2021B009）；国家中医药管理局中医药创新团队项目（ZYYCXTD-C-202205） |
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| 中文摘要: |
| 目的：观察捏筋脉位疗法联合昂丹司琼预防顺铂所致恶心呕吐的疗效。方法：选取2019年4月至2020年1月中国中医科学院广安门医院肿瘤科收治的恶性肿瘤患者65例作为研究对象，根据入院顺序分为观察组（n=34）和对照组（n=31）。2组均给予静脉注射昂丹司琼，观察组给予捏筋脉位手法操作，对照组给予假按摩治疗。比较2组急性期、延迟期化疗所致呕吐控制率（CIV-CR）、化疗所致恶心控制率（CIN-CR）、完全控制率（CCR）、恶心严重程度、呕吐次数和生命质量（QoL）。结果：与对照组比较，观察组延迟性CIV-CR增加了27.8%（P=0.018），延迟性CIN-CR增加了27.4%（P=0.022），在延迟期的呕吐次数和恶心严重程度均显著下降（P=0.013;P=0.016）。但2组在急性期的CIV-CR（P=0.413）、CIN-CR（P=0.804）、CCR（P=0.152）、呕吐次数（P=0.308）和恶心严重程度（P=0.514），差异无统计学意义（P>0.05）。此外，捏筋脉位疗法改善了QoL（P=0.003），特别是在身体健康（P=0.001）和功能健康方面（P=0.023）。结论：捏筋脉位疗法联合昂丹司琼可改善延迟期的CIN-CR、CIV-CR、呕吐次数、恶心严重程度以及生合质量。 |
| English Summary: |
| To observe the clinical efficacy of Nie Jinmaiwei massage in preventing nausea and vomiting caused by cisplatin-included chemotherapy regimens.Methods:A total of 65 cases who received cisplatin-included chemotherapy regimens in Guang'anmen Hospital,China Academy of Chinese Medical Sciences from April 2019 to January 2020 were selected as research subjects.They were divided into observation group(n=34) and control group(n=31) according to the order of admission.In addition to intravenously administered ondansetron in both groups,the observation group was given Nie Jinmaiwei massage and the control group received sham massage treatment.The chemotherapy-induced vomiting control rate(CIV-CR),chemotherapy-induced nausea control rate(CIN-CR),complete control rate(CCR),severity of nausea,number of vomiting and quality of life(QoL) in acute and delayed phases were compared between the two groups.Results:Compared with the control group,the observation group had 27.8% increase in delayed CIV-CR(P=0.018),and 27.4% in delayed CIN-CR(P=0.022),and the number of vomiting and the severity of nausea were less in the observation group than those in the control group(1.1 vs.5.0,P=0.013; 2.2 vs.3.9,P=0.016,respectively) in delayed phase.However,there were no differences in CIV-CR(P=0.413),CIN-CR(P=0.804),CCR(P=0.152),number of vomiting(P=0.308) and severity of nausea(P=0.514) in acute phase.Furthermore,Nie Jinmaiwei massage improved QoL(90.7 vs.83.5,P=0.003),especially in terms of functional well-being(24.1 vs.21.9,P=0.023).Conclusion:Nie Jinmaiwei massage combined with ondansetron for chemotherapy-included nausea and vomiting could improve CIN-CR,CIV-CR and QoL,and decrease the number of vomiting and the severity of nausea in delayed phase.. |
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