| 引用本文:林飞1，郑红刚1，周雍明1，李丛煌1，高劲1,2，于惠博1,2，朴炳奎1.朴炳奎解毒法治疗靶向所致皮疹的经验挖掘及应用研究[J].世界中医药,2022,(11):. |
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| 朴炳奎解毒法治疗靶向所致皮疹的经验挖掘及应用研究 |
| Piao Bingkui's Experience and Application in the Treatment of Targeted Drugs-induced Rash by Removing Toxin |
| 投稿时间：2022-04-20 |
| DOI：10.3969/j.issn.1673-7202.2022.11.006 |
| 中文关键词: 扶正解毒 肺癌 皮疹 数据挖掘 经验传承 @ 朴炳奎 |
| English Keywords:Reinforcing healthy qi and removing toxin Lung cancer Rash Data analysis Experience inheritance @ Piao Bingkui |
| 基金项目:国家中医药管理局委托办事项目（GZY-GCS-2018-071）；国家中医药创新团队（ZYYCXTD-C-202205）；国家自然科学基金面上项目（82174463） |
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| 中文摘要: |
| 目的：通过数据挖掘的方法，探寻朴炳奎教授治疗肺癌靶向治疗患者及靶向治疗导致皮疹患者的用药规律，用客观数据总结其临床经验。方法：采用联机处理分析和复杂网络分析方法，对朴炳奎教授临床诊疗电子信息化模板的数据库中37例肺癌靶向治疗患者的病历资料进行回顾性分析（其中包含14例皮疹患者）。结果：通过数据挖掘，显示出朴师处方的核心思想以益气健脾为主，结合化痰祛湿、清热解毒为治则，体现出扶正与祛邪、辨病与辨证、局部与整体相结合的学术思想。结合专家访谈的形式，确立解毒消疹方的组成。结论：数据挖掘的结果与朴师治疗肺癌的扶正固本、祛邪解毒相结合的中西医结合学术思想得到了相互印证；确立了解毒消疹方的组成，即白芍、金银花、地肤子、蝉蜕。 |
| English Summary: |
| To explore professor Piao Bingkui's medication rule of targeted therapy for lung cancer through data mining,so as to display his clinical experience with objective data.In addition,the medication rules of patients with rashes in the course of targeted therapy for lung cancer were screened,and in-depth interview was performed to further determine professor Piao's experience in treating rashes caused by targeted therapy.Methods:With the online analytical processing and complex network analysis,37 lung cancer patients treated by targeted therapy(including 14 patients with rash) in the electronic clinical diagnosis and treatment information database of professor Piao were analyzed retrospectively.Results:Data mining revealed that the core idea of professor Piao's prescription was replenishing qi and invigorating spleen,combined with resolving phlegm,eliminating dampness,clearing heat and detoxifying as the treatment principle,reflecting the academic thought of reinforcing healthy qi and eliminating pathogen,disease and syndrome differentiation,local and whole combination.Combining expert interview,we also specified the composition of Jiedu Xiaozhen Prescription for treating rash.Conclusion:The results of data mining and professor Piao's thoughts on treating lung cancer were mutually confirmed,and Jiedu Xiaozhen Prescription was composed of Radix Paeoniae Alba,Flos Lonicerae,Fructus Kochiae and Periostracum Cicadae. |
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