To study the promoting effect of aqueous extract of Salvia miltiorrhiza on vascular endothelial cell damage repair in rats.Methods:A total of 60 healthy Wistar rats were divided into four groups,normal control group,model group,and low dose group(1.5 g/d) and high dose group(3 g/d) of S.miltiorrhiza aqueous extract,15 in each group.The model of vascular endothelial injury in rats was established with adrenaline hydrochloride solution,and serum of these rats was collected from the tail vein on days 1,8 and 17 after adrenalin injection.Then von Willebrand factor(vWF),vascular endothelial growth factor(VEGF),monocyte chemoattractant protein-1(MCP-1) and interleukin 10(IL-10) were tested.Results:The content of vWF,VEGF and MCP-1 in the aqueous extract groups was lower and the content of IL-10 was higher than those in the model group.Conclusion:The aqueous extract of S.miltiorrhiza had obvious promoting effect on vascular endothelial repair in injured rats.