世界中医药
文章摘要
引用本文:史中斐,郑艺君,刘平,张坤漓,吕咪,王凤云.基于数据挖掘的《普济方》治疗反酸用药规律研究[J].世界中医药,2022,(11):.  
基于数据挖掘的《普济方》治疗反酸用药规律研究
Medication Rule of Acid Regurgitation Treatment in Formulary of Universal Relief Based on Data Mining
投稿时间:2021-09-17  
DOI:10.3969/j.issn.1673-7202.2022.11.021
中文关键词:  反酸  《普济方》  数据挖掘  用药规律  调补中焦  多法并用  多脏同调
English Keywords:Acid regurgitation  Formulary of Universal Relief  Data mining  Medication rule  Regulating and tonifying middle energizer  Combination of multiple methods  Simultaneous regulation of multiple zang-organs
基金项目:国家自然科学基金面上项目(81774303,81373580);国家科技重大专项(2019ZX09201005-003);北京市科技计划项目(Z161100000116046)
作者单位
史中斐,郑艺君,刘平,张坤漓,吕咪,王凤云 中国中医科学院西苑医院北京100091 
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中文摘要:
      目的:利用数据挖掘方法对《普济方》中治疗反酸处方进行统计分析,从而为临床治疗反酸用药提供参考。方法:筛选《普济方》中用于治疗反酸的方剂,利用古今医案云平台V2.2.2、SPSS Statistics 26.0及SPSS Modeler 18.0软件对方药进行频次统计、关联分析、聚类分析,挖掘高频应用的中药、常用药对及药物组合。结果:纳入符合要求的方剂202首,共使用190种中药,其中频次≥20次的中药25味,排名前3位的是陈皮、生姜、肉桂;药性以温性、平性居多,药味以辛味、苦味为主,归经主要入脾经、胃经;关联规则分析得到18组药对;聚类分析得到4类药物组合。结论:《普济方》治疗反酸以恢复中焦气机升降为核心目标,重视对中焦的调补,采用益气健脾、燥湿化痰、疏肝行气、和胃降浊、温阳散寒等治法,多法并用,多脏同调,为临床治疗反酸提供参考。
English Summary:
      To analyze the prescriptions for acid regurgitation in Formulary of Universal Relief by data mining,so as to provide reference for clinical treatment of acid regurgitation.Methods:The prescriptions used to treat acid regurgitation in Formulary of Universal Relief were screened,and the frequency statistics,association analysis and cluster analysis were carried out by ancient and modern medical record cloud platform(V2.2.2),SPSS statistics 26.0 and SPSS modeler 18.0 to mine the high-frequency medicinal materials,common drug pairs and drug combinations.Results:A total of 202 prescriptions were included,involving 190 Chinese medicinal materials,of which 25 had the frequency≥20,and the top three were Pericarpium Citri Reticulatae,Rhizoma Zingiberis Recens and Cortex Cinnamomi.The medicinal materials were mostly warm and moderate in property,and pungent and bitter in flavor,and mainly acted on spleen and stomach channels.Eighteen drug pairs and four drug combinations were obtained by association analysis and cluster analysis,respectively.Conclusion:The core goal of acid regurgitation treatment in Formulary of Universal Relief was to restore the ascending and descending of qi movement in middle energizer,focusing on regulating and tonifying middle energizer.The treatment principles were replenishing qi,invigorating spleen,drying dampness,resolving phlegm,soothing liver,moving qi,harmonizing stomach,descending turbid,warming yang and dissipating cold,with combination of multiple methods and simultaneous regulation of multiple zang-organs.
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