| 引用本文:吴丹桐1，苏泽琦2，孟涵1，苏吾特1，薄荣强1，施月1，安荣仙1，李萍1，丁霞3.基于专利数据研究中药复方治疗慢性萎缩性胃炎的用药规律[J].世界中医药,2022,(11):. |
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| 基于专利数据研究中药复方治疗慢性萎缩性胃炎的用药规律 |
| Medication Rules of Traditional Chinese Medicine Patent Compounds for Chronic Atrophic Gastritis Based on Data Ming |
| 投稿时间：2021-10-26 |
| DOI：10.3969/j.issn.1673-7202.2022.11.024 |
| 中文关键词: 数据挖掘 慢性萎缩性胃炎 专利 中药复方 用药规律 关联规则 复杂网络 中医传承辅助平台 |
| English Keywords:Data mining Chronic atrophic gastritis Patents Traditional Chinese Medicine compounds Medication rule Association rule Complex network Traditional Chinese Medicine Inheritance Platform |
| 基金项目:国家自然科学基金重点项目（81630080）——Ezrin-ACAP4-ARF6信号轴应答肿瘤转移前微环境的效应机制研究；国家自然科学基金重大研究计划项目（92059102）——基于相分离激酶活性报告系统的胃癌炎癌转化关键信号轴可视化研究；国家自然科学基金面上项目（82074243）——基于Ezrin-ACAP4通路的调气活血养阴法调控胃酸分泌阻断慢性萎缩性胃炎“炎癌转化”的机制研究；北京中医药大学东直门医院2020科技创新专项（DZMKJCX-2020-021）——慢性胃炎“炎癌转化”不同病理阶段胃内酸环境动态变化研究 |
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| 中文摘要: |
| 目的：通过专利分析，挖掘慢性萎缩性胃炎中药复方用药规律。方法：检索国家知识产权局专利库中治疗慢性萎缩性胃炎的中药专利复方数据，使用中医传承辅助平台统计药物使用频次，分析关联规则，构建复杂网络等。结果：纳入专利复方189条，高频药物有白术、甘草等。药性以温、寒、平居多，药味以苦、甘、辛多见，归经以脾、胃、肝经为主。最常用对药为“白术-茯苓”；最常用角药为“延胡索-白术-白芍”；高置信度关联规则有“甘草，茯苓→白术”等；熵层次聚类新处方有“厚朴-枳实-鸡内金-茵陈”等。结论：慢性萎缩性胃炎以脾胃虚弱为基本病机，以虚实夹杂为病理特点，以血瘀为重要病理趋势，治疗应以健脾益气为基础治法，重视活血化瘀法以求病理机转。 |
| English Summary: |
| To study the medication rule of traditional Chinese medicine(TCM) compounds in the treatment of chronic atrophic gastritis.Methods:The patent library of China National Intellectual Property Administration was searched to obtain the patent data of TCM compound for treating chronic atrophic gastritis.Then the data were imported into the Traditional Chinese Medicine Inheritance Support System(V2.5) for frequency statistics,association rule analysis,and complex network construction.Results:A total of 189 TCM patent compounds were included.The high-frequency Chinese medicinal materials were Rhizoma Atractylodis Macrocephalae and Radix Glycyrrhizae.The medicinal materials were mainly warm,cold,moderate in property,and bitter,sweet,pungent in flavor,and mainly acted on spleen,stomach,and liver.The most common drug pair and triple drug combination were Rhizoma Atractylodis Macrocephalae-Poria and Rhizoma Corydalis-Rhizoma Atractylodis Macrocephalae-Radix Paeoniae Alba,respectively.The association rule with high confidence was Radix Glycyrrhizae,Poria→Rhizoma Atractylodis Macrocephalae,and the new obtained prescription via entropy-based hierarchical clustering was Cortex Magnoliae Officinalis-Fructus Aurantii Immaturus-Endothelium Corneum Gigeriae Galli-Herba Artemisiae Scopariae.Conclusion:The basic pathogenesis of chronic atrophic gastritis was deficiency of spleen and stomach,with deficiency-excess in complexity as the pathological characteristics and blood stasis as the important disease trend.The treatment should be based on invigorating spleen and replenishing qi and focus on activating blood and resolving stasis. |
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