To explore the rules of acupoint selection in the treatment of heart pain by acupuncture and moxibustion in ancient literature based on data mining,so as to provide reference for clinical acupuncture and moxibustion treatment of heart pain.Methods:The retrieval system of acupoint indications in ancient acupuncture and moxibustion literature was searched to screen the literature and extract acupoint prescriptions according to inclusion and exclusion criteria.Descriptive analysis,association analysis and factor analysis were performed using IBM SPSS statistics 25.0 and IBM SPSS modeler 18.0.Results:A total of 394 effective prescriptions were selected from 73 ancient books such as Huangdi's Internal Classic and A Brife History of Chinese Acupuncture and Moxibustion Therapy.Descriptive analysis showed that the top five acupoints in the treatment of heart pain were Zhongwan(CV 12),Shangwan(CV 13),Juque(CV 14),Daling(PC 7) and Neiguan(PC 6); conception vessel(CV),pericardial meridian and bladder meridian were the most frequently selected meridians; in terms of specific points,five transport points,alarm point and source point were mainly selected; the high-frequency acupoint combinations were Zhongwan-Shangwan,Juque-Zhongwan and Neiguan-Daling.Data mining indicated that the core acupoint prescription for treating heart pain was Zhongwan-Shangwan-Juque.Nine common factor groups were extracted by factor analysis.Conclusion:In ancient literature,heart meridian or the corresponding exterior-interior meridians and acupoints were generally selected in the acupuncture and moxibustion treatment of heart pain.For the heart pain caused by the disorder of qi movement in the other zang-fu organs,acupuncture and moxibustion for the primary organ or the acupoints of the corresponding exterior-interior organ meridians was performed; in case of combined symptoms observed in the other zang-fu organs,relevant organ meridians should be chosen for symptomatic treatment.