世界中医药
文章摘要
引用本文:崔竞文1,张少乾1,刘苏槿1,张小敏1,陈潮光2,敖日格乐3,徐秀娟4,佟海英1.蒙医常用524首方剂处方的用药规律[J].世界中医药,2022,(11):.  
蒙医常用524首方剂处方的用药规律
Medication Rules of 524 Prescriptions Commonly Used in Mongolian Medicine
投稿时间:2021-09-14  
DOI:10.3969/j.issn.1673-7202.2022.11.026
中文关键词:  蒙医  方剂  蒙药  数据挖掘  频次统计  关联规则  聚类分析  处方用药规律
English Keywords:Mongolian medicine  Prescription  Mongolian medicine  Data mining  Frequency statistics  Spatiotemporal association rule  Cluster analysis  Medication rule of prescriptions
基金项目:国家重点研发计划项目(2018YFC1708200,2018YFC1708206)
作者单位
崔竞文1,张少乾1,刘苏槿1,张小敏1,陈潮光2,敖日格乐3,徐秀娟4,佟海英1 1 北京中医药大学中医学院北京100029 2 北京中医药大学坪山国医堂深圳518000 3 呼和浩特市蒙医中医医院蒙医骨病中心呼和浩特010010 4 包头医学院药学院包头014040 
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中文摘要:
      目的:探讨蒙医常用方剂处方的用药规律。方法:收集、整理、筛选《中华人民共和国卫生部药品标准·蒙药分册》《中国医学百科全书·蒙医学》《传统蒙药与方剂》《蒙医方剂学》(蒙文版蒙医教材)中的常用蒙医方剂,从剂型、方剂类型、用药频次、药物分类、性味、药效等角度进行频次统计、关联规则与聚类分析,探讨其处方用药规律。结果:共筛选出524首蒙医常用方剂;最常用剂型为散剂;五脏类方为主要方剂类型;高频药物依次为诃子、红花、栀子等;药物分类中祛巴达干药物使用频次最高,占比16.36%,其次为清热类药物、镇赫依类药物等;药性以凉性为主,占43.33%;药味以苦味为主,占45.55%;药物效能中轻性频次最高,占41.39%,其次为钝、燥、糙等;19个高频药对中有13个涉及镇赫依类药物,9组核心药物内“川楝子→栀子”的置信度最高;系统聚类得出6个药物组合,包括4个凉性组合、2个温性组合。结论:蒙医方剂善用散剂,重治五脏,习用诃子;围绕“六基症”对“证”组方;习用性凉,味苦,效轻、锐、燥、糙之药,常用对药以镇赫依类药物为主,置信度最高的核心药物组合为“川楝子→栀子”;聚类组合以凉性为主,与药性结果互为验证。
English Summary:
      To explore the medication rules of Mongolian medicine prescriptions.Methods:Common Mongolian medicine prescriptions were comprehensively collected and screened from Drug Standards of the Ministry of Health of the People's Republic of China·Mongolian Medicines,Encyclopedia of Chinese Medicine·Mongolian Medicine,Traditional Mongolian Medicine and Prescription,and Mongolian Medicine Prescription(Mongolian medicine textbooks in Mongolian).Frequency statistics,association rules and cluster analysis were carried out from the perspectives of dosage form,prescription type,medication frequency,drug classification,property flavor and efficacy to explore the medication rules of the prescriptions.Results:A total of 524 common Mongolian prescriptions were screened,with powder as the most commonly used dosage form,and five zang-organ prescriptions the main prescription types.The high-frequency medicinal materials were Fructus Chebulae,Flos Carthami and Fructus Gardeniae,and those for Badagan treatment had the highest frequency,accounting for 16.36%,followed by antipyretic medicines and tranquilizing Heyi medicines.The medicines were mainly cool in property(43.33%) and bitter in flavor(45.55%),and the frequency of lightness in drug efficacy was the highest,accounting for 41.39%,followed by bluntness,dryness and roughness.Of the 19 high-frequency drug pairs,13 were related to tranquilizing Heyi,and among the nine core drug combinations,Fructus Meliae Toosendan→Fructus Gardeniae had the highest confidence.Six drug combinations were obtained by cluster analysis,including four cool combinations and two warm combinations.Conclusion:In Mongolian medicine,powder was frequently adopted and the treatment focused on five zang-organs,with Fructus Chebulae selected mostly.The prescriptions were developed aiming at the six basic symptoms,and cool and bitter medicines with lightness,bluntness,dryness and roughness were mostly chosen.For drug pairs,those for tranquilizing Heyi were dominant,and the core drug combination with the highest confidence was Fructus Meliae Toosendan→Fructus Gardeniae.Cluster combinations were dominated by coolness,and mutually validated with the medicinal results.
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