To explore the treatment of unexplained recurrent spontaneous abortion based on the concept of differentiation and treatment of gestational diseases in the Synopsis of the Golden Chamber(Jin Gui Yao Lue).Methods:This study clarified and discussed the diagnosis and treatment ideas and prescription composition for miscarriage prevention，abdominal discomfort in pregnancy，and bleeding during pregnancy in accordance with the pertinent records of gestational diseases in the Synopsis of the Golden Chamber.Moreover，in-depth descriptions and analyses of the syndrome differentiation theory used in disease treatment as well as the theory of medication during pregnancy without death were provided in this article.Results:Danggui Powder and Baizhu Powder for miscarriage prevention，Danggui Shaoyao Powder for abdominal discomfort in pregnancy，and Jiaoai Decoction for bleeding during pregnancy were commonly used by ancient and modern doctors.The treatment of unexplained recurrent spontaneous abortion can be influenced by Zhang Zhongjing's theories on the management of gestational diseases.Conclusion:The Synopsis of the Golden Chamber has a thorough medical description of gestational diseases，strict compatibility of prescriptions，a careful selection of medicines，and exceptional curative effects，which provides a fresh，trustworthy foundation for the diagnosis and treatment of unexplained recurrent spontaneous abortion.