| 引用本文:潘丽1,2，荆琳2，谢雁鸣1，高阳1，杨云云3.基于倾向性评分对丹参川芎嗪注射液治疗骨科疾病的临床实效研究[J].世界中医药,2022,(12):. |
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| 基于倾向性评分对丹参川芎嗪注射液治疗骨科疾病的临床实效研究 |
| Clinical Efficacy of Danshen Chuanxiongqin Injection in Treatment of Orthopedic Diseases Based on Propensity Score |
| 投稿时间：2020-08-29 |
| DOI：10.3969/j.issn.1673-7202.2022.12.018 |
| 中文关键词: 倾向性评分 丹参川芎嗪注射液 骨科疾病 疗效 真实世界 医院信息系统 Logistic回归分析 回顾性研究 |
| English Keywords:Propensity score Danshen Chuanxiongqin Injection Orthopedic disease Curative effect Real-world Hospital Information System Logistic regression analysis Retrospective study |
| 基金项目:国家重点研发计划项目（2018YFC1707400）——十种中成药大品种和经典名方上市后治疗重大疾病的循证评价及其效应机制的示范研究项目 |
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| 中文摘要: |
| 目的：评价骨科疾病患者使用与不使用丹参川芎嗪注射液的疗效差异。方法：从18家全国三甲医院信息系统(HIS)提取数据，选取使用丹参川芎嗪注射液患者1 370例作为研究对象，按照使用和未使用丹参川芎嗪治疗骨科疾病患者以性别、年龄、入院病情1:1匹配，匹配后使用丹参川芎嗪注射液组（丹川组）与未使用丹参川芎嗪注射液组（对照组）均260例，将治愈、好转重新编码为有效，其他、无效、死亡编码为无效，对2组间的有效治疗率进行评价。运用倾向性评分对2组间混杂因素进行平衡，通过Logistic回归分析比较2组治疗骨科疾病的疗效。结果：Logistic回归分析比较，2组骨科疾病治疗效果差异有统计学意义（P<0.05）。结论：丹参川芎嗪注射液治疗骨科疾病优于未使用丹参川芎嗪注射液。但基于本研究是真实世界的回顾性研究，且倾向性评分无法对未知的混杂因素进行平衡，故研究具有一定的局限性。仍须大量的样本数据进行更精确的分析，为临床指导用药提供参考。 |
| English Summary: |
| To evaluate the clinical efficacy of Danshen Chuanxiongqin Injection(DSCXQ) in the treatment of orthopedic diseases.Methods:Data were extracted from the Hospital Information System(HIS) of 18 national Grade-Ⅲ Class-A hospitals，and there were 1 370 cases treated with DSCXQ.According to gender，age，and hospitalization conditions，the patients with orthopedic diseases treated with and without DSCXQ were matched at 1:1.A DSCXQ group(n=260) and a control group(n=260) were set up.The cured and improved were recoded as effective，and others，the invalid and dead were coded as ineffective.The effective rates of the two groups were evaluated.The propensity score was used to balance the confounding factors between the two groups，and the efficacy of the two groups in the treatment of orthopedic diseases was compared by Logistic regression analysis.Results:As revealed by Logistic regression analysis，there was a significant difference between the DSCXQ group and the control group in the treatment of orthopedic diseases(P<0.05).Conclusion:The efficacy in the DSCXQ group was superior to that in the control group.However，because this study is a real-world retrospective study，the propensity score cannot balance unknown confounding factors，resulting in certain limitations.Massive sample data are still required for more accurate analysis，which can provide references for clinical guidance of medication. |
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