To determine the appropriate amount of topdressing to achieve high-quality Fritillaria cirrhosa (FC) and provide theoretical and technical support for the cultivation of high-yield and high-quality medicinal materials of FC according to the investigation of the effects of different fertilizers.Methods:The 5-year-old FC at the initial flowering stage was topdressed with high-,medium-,and low-doses of nitrogen (N),phosphate (P) and potassium (K) fertilizers.Furthermore,the effects of different types and dosages of fertilizers on photosynthetic parameters,fluorescence parameters,main agronomic characters,and total alkaloid content were analyzed.Results:The photosynthetic parameters and fluorescence parameters of FC were significantly increased and then decreased after topdressing of different dosages of N,P,and K fertilizers,respectively.Moreover,leaf width was significantly affected by the topdressing of P and K fertilizers.With fruit weight,total seed number per fruit,seed setting rate,1 000-seed weight,bulb fresh weight,and total alkaloid content as comprehensive evaluation indexes,the optimal fertilization dosages for producing the high-yield and high-quality of FC were 20 g/m2 N fertilizer,250 g/m2 P fertilizer,and 75 g/m2 K fertilizer.Under the optimum fertilization,the utilization effect of different fertilizers was evaluated as K>P>N.Conclusion:Scientific and rational topdressing of N,P,and K fertilizers in the flowering stage can improve the yield and quality of FC,which can provide theoretical support for the improvement of fertilization technology for artificial cultivation of FC.