To analyze the compatibility rules of Chinese patent medicines with the effect of “simultaneous treatment of brain and heart diseases” and thus to lay a basis for the clinical application of this method.Methods:The prescriptions of Chinese patent medicines with the effect of simultaneous treatment of brain and heart diseases were retrieved from “yaoZH” database and then Excel 2010,SPSS Modeler14.1,SPSS Statistics 23.0 were employed for analyzing the compatibility rules.Results:A total of 37 prescriptions of Chinese patent medicines were screened out,involving 133 Chinese medicinals with cumulative frequency of 335.The 6 Chinese medicinals with high cumulative frequency were Radix Salviae Miltiorrhizae,Rhizoma Ligustici Chuanxiong,Radix Angelicae Sinensis,Radix Astragali seu Hedysari,Lumbricus,and Flos Carthami.The medicinals are mainly warm,plain,and cold in property,and sweet,bitter,and pungent in flavor,with the meridian tropism of liver,spleen,and heart.They were classified into the blood-activating and stasis-resolving medicinals,tonifying medicinals,wind-extinguishing and convulsions-stopping medicinals,and heat-clearing medicinals.The association rules analysis yielded 24 common medicinal pairs,such as the Radix Salviae Miltiorrhizae-Rhizoma Ligustici Chuanxiong combination.Cluster analysis classified the high-frequency medicinals into the qi-replenishing and blood-activating medicinals and qi-moving and blood-activating medicinals.The representative prescriptions were Buyang Huanwu Decoction and Tongyu Decoction.In addition,the 37 Chinese patent medicines mainly targeted 12 traditional Chinese medicine (TCM) syndromes,such as syndrome of blood stasis,syndrome of qi deficiency and blood stasis,and syndrome of qi stagnation and blood stasis.Conclusion:According to the basic treatment principle of activating blood and resolving stasis,Chinese patent medicines with the effect of “simultaneous treatment of brain and heart diseases” mainly contain the blood-activating and stasis-resolving medicinals,with the deficiency-tonifying medicinals,wind-extinguishing and convulsions-stopping medicinals,and heat-clearing medicinals as auxiliary.This study lays a basis for the clinical application of the method of “simultaneous treatment of brain and heart diseases” and the development of new medicines.