To explore the relationship of syndrome of yin deficiency and liver depression with neuro-endocrine-immune network in senile depression.Methods:Sixty-four patients of senile depression with syndrome of yin deficiency and liver depression treated in Xiyuan Hospital,China Academy of Chinese Medical Sciences from January 2010 to December 2012 were selected as the observation group and compared with 50 healthy old people(control group).The levels of 5-hydroxytryptamine(5-HT),norepinephrine(NE),dopamine(DA),cortisol(CS),adrenocorticotropic hormone(ACTH),and corticotropin-releasing hormone(CRH),interleukin 6(IL-6),interleukin 1 beta(IL-1β),and tumor necrosis factor-alpha(TNF-α) in peripheral blood were measured for both groups.Results:The levels of 5-HT,DA,CS,and CRH in the observation group were significantly different from those in the control group(P<0.05).The observation group had higher levels of immune cytokines IL-6 and TNF-α than the control group(P<0.05).The results showed that the neuro-endocrine-immune network was maladjusted in aged depression patients with the syndrome of yin deficiency and liver depression.Conclusion:The syndrome of yin deficiency and liver depression in senile depression may be closely related to the neuro-endocrine-immune disorder.Regulating the neuro-endocrine-immune network by nourishing yin and regulating liver may be more beneficial to the recovery of patients.