Anti-tumor Chinese patent medicines are one of the important means of treating tumors with Chinese medicine.However,the broad indications and insufficient evidence-based evidence seriously restrict the clinical promotion and application.It is necessary to continuously carry out the post-marketing study to highlight the efficacies and advantages of Chinese patent medicine treatment.Based on this,this paper put forward the key points of the post-marketing study of closed-loop anti-tumor Chinese patent medicines,which was “to promote research with evaluation and promote evaluation with research”.First of all,the clinical medication regimen and evidence-based evaluation should be improved based on the evaluation of the safety,efficacy,and economy of anti-tumor Chinese patent medicines after extensive clinical application.Secondly,based on the results of re-evaluation,the valuable clinical hypotheses should be excavated and creatively proposed,with the conduction of open exploration studies.The hypotheses should be evaluated and verified,and the value and clinical positioning of anti-tumor Chinese patent medicines should be strengthened.The continuous feedback cycle is the foundation to accelerate the transformation of anti-tumor Chinese patent medicines,and makes contributions to precise medication and enhancement of industrial confidence,thus realizing the normalization,standardization,and modernization of Chinese medicine research and development.