Cancer-related fatigue(CRF) is a subjective distressing feeling of tiredness or exhaustion among cancer patients in physiological,emotional,and cognitive aspects.Our research team has been shocked by the theoretical and clinical advantages of traditional Chinese medicine(TCM) in managing CRF in literature and clinical studies.Based on the characteristics of the pathological mechanism of CRF in the era of precision medicine,this paper believed that the concept of holism and the concept of syndrome differentiation and treatment in TCM were particularly suitable for the complex and changeable characteristics of CRF pathogenesis and the needs of the era of individualized diagnosis and treatment.TCM differentiation and treatment of CRF had the advantages of rich theories,advanced concepts,and diverse methods.In addition,this paper tried to explore strategies for TCM differentiation and treatment of CRF from the traditional macro-diagnosis and treatment to the micro-diagnosis and treatment in the era of precision medicine according to existing evidence.It aimed to provide new ideas for inheriting the advantages of TCM treating CRF based on syndrome differentiation and treatment,responding to the call of the times,optimizing the differentiation and treatment content,and improving clinical efficacies.