The morbidity of coronary heart disease with anxiety and depression increases year by year,but its recognition rate and diagnosis and treatment rate are low.At present,western medicine believes that the pathogenesis of coronary heart disease with anxiety and depression may be related to inflammatory reaction,neuroendocrine system,platelet activation,endothelial injury,etc.,while traditional Chinese Medicine(TCM) holds that the deficiency of Qi,blood,Yin and Yang,Qi stagnation,blood stasis,turbid phlegm are the main etiology and pathogenesis.The treatment is mainly based on secondary prevention of coronary heart disease,combined with traditional Chinese and western medicine and non-drug treatment of anxiety and depression,to effectively control the risk factors.This paper reviewed the pathogenesis and treatment of coronary heart disease with anxiety and depression.