Abstract:Post-stroke depression(PSD) is a common mental illness associated with stroke.Patients suffering from PSD often fail to work normally and need to be cared,and they even tend to commit suicide,which is widely concerned by the society.From ancient to modern times,there have been numerous studies of PSD.In ancient times,theories of “five depression” and “disease location” were found.Nowadays,there are studies on biological factors such as inflammatory mediators,neurotransmitters and hypothalamus-pituitary-adrenal axis.This paper mainly discussed the mechanism of PSD through five zang organs,including the relevant progress of traditional Chinese medicine(TCM) theory and modern medical research,aiming to provide more clinical ideas for the treatment of PSD.