Gastroesophageal reflux disease(GERD)，showing typical reflux and heartburn symptoms，seriously affects the quality of life because it is difficult to be cured and easy to reoccur.The occurrence and development of GERD are affected by many factors，especially the psychological factors.The incidence of this disease shows a noteworthy upward trend with the accelerating pace of life.Western medical therapies using acid suppressants and gastroprokinetic agents mainly aim at relieving symptoms and complications，with limited efficacy.Chinese medicine compound prescriptions can offer individualized and multi-target therapy，with widely verified therapeutic effect.By reviewing the research progress，we comprehensively described the mechanisms of Chinese medicine compound prescriptions in the treatment of GERD in this paper，which included reducing the transient relaxation of lower esophageal sphincter，esophageal sensitivity to acid，inflammatory response，anxiety，and depression.