Systematic thinking，also known as holistic thinking，aims to learn the research object in an overall and interrelated manner，representing the developed dialectical thinking.Clinical diagnosis and treatment of repeated failure in the in-vitro fertilization-embryo transfer(IVF-ET) is guided by systematic thinking，which focuses on the overall syndrome differentiation of multiple disease positions，pathogenesis of contradictions，and complex pathogenesis，comprehensively considering a variety of influencing factors in the physique，emotion，adjustment，and environment of patients.Combining regulation，maintenance，and treatment，systematic thinking guides the use of both cold and heat medicinal herbs in prescriptions and the simultaneous regulation of deficient and excessive symptoms，so as to realize the multi-target，multi-pathway，and multi-mechanism treatment of this disease.