To evaluate the effects of Xuefu Zhuyu Decoction on inflammatory factors in cardiovascular diseases.Methods:Pubmed，Embase，Cochrane Library，CNKI，CSPD，and CCD were searched for randomized controlled trials(RCTs) of Xuefu Zhuyu Decoction against inflammatory factors in cardiovascular diseases with the retrieval strategy of the combination of subject terms and free terms.The quality of included RCTs was assessed by the Cochrane Handbook for Systematic Reviews of Interventions.The data were extracted，followed by Meta-analysis with Revman5.3 software.Results:Twenty-three RCTs were included，involving 2 274 cases.Meta-analysis showed that Xuefu Zhuyu Decoction could significantly reduce the levels of inflammatory factors such as CRP(SMD=-2.04，95%CI -2.82 to -1.26，P<0.000 01)，hs-CRP(SMD=-1.46，95%CI -1.9 to -0.96，P<0.000 01)，TNF-α(SMD=-1.25，95%CI -1.68 to -0.83，P<0.000 01)，and IL-6(SMD=-1.08，95%CI -1.45 to -0.70，P=0.003).Conclusion:Xuefu Zhuyu Decoction could reduce the expression of inflammatory factors and control inflammatory responses to improve the symptoms of cardiovascular diseases.Since the accuracy of this conclusion was limited by the quality of the included research articles，more high-quality RCTs are needed to provide reliable evidence-based medicine support.