| 引用本文:赵红玉1，熊枫2，刘新敏1.康妇消炎栓联合抗生素治疗慢性盆腔炎的系统评价和Meta分析[J].世界中医药,2022,(22):. |
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| 康妇消炎栓联合抗生素治疗慢性盆腔炎的系统评价和Meta分析 |
| Systematic Review and Meta-analysis of Kangfu Xiaoyan Suppository Combined with Antibiotics in the Treatment of Chronic Pelvic Inflammatory Disease |
| 投稿时间：2020-12-16 |
| DOI：10.3969/j.issn.1673-7202.2022.22.010 |
| 中文关键词: 康妇消炎栓 抗生素 慢性盆腔炎 有效性 安全性 系统评价 Meta分析 |
| English Keywords:Kangfu Xiaoyan Suppository Antibiotics Chronic pelvic inflammatory disease Efficacy Safety System review Meta-analysis |
| 基金项目:国家自然科学基金项目（8167150431） |
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| 中文摘要: |
| 目的：系统评价康妇消炎栓联合抗生素治疗慢性盆腔炎的有效性及安全性。方法：检索Embase，Cochrane Library，Medline，中国生物医学文献数据库（CBM），国家知识基础设施数据库（CNKI），中国学术期刊数据库（CSPD）和中文科技期刊数据库（CCD），筛选出康妇消炎栓联合抗生素治疗慢性盆腔炎的随机对照试验文献，检索时限均为从建库至2020年10月。由2名研究者按照纳入和排除标准独立进行文献筛选及资料提取，采用Cochrane系统评价手册进行质量评价，采用RevMan 5.3软件进行数据分析。结果：共纳入44个随机对照试验，共5 143例患者。康妇消炎栓联合抗生素治疗慢性盆腔炎在提高总有效率（RR=4.84，95%CI为3.99~5.86，P<0.000 01），缩短腹痛持续时间（MD=-2.61，95%CI为-3.12~-2.10，P<0.000 01）、腹部坠胀时间（MD=-2.54，95%CI为-3.22~-1.85，P<0.000 01）及白带异常持续时间（MD=-2.82，95%CI为-3.26~-2.39，P<0.000 01）等方面优于单独使用抗生素。康妇消炎栓联合抗生素治疗可降低不良反应发生率（RR=0.67，95%CI为0.49~0.92，P=0.01＜0.05）。结论：基于现有临床证据，康妇消炎栓联合抗生素治疗慢性盆腔炎优于单纯的抗生素治疗。 |
| English Summary: |
| To systematically evaluate the efficacy and safety of Kangfu Xiaoyan Suppository combined with antibiotics in the treatment of chronic pelvic inflammatory disease(CPID).Methods:Embase，Cochrane Library，Medline，CBM，CNKI，CSPD，and CCD were searched for randomized controlled trials(RCTs) of Kangfu Xiaoyan Suppository combined with antibiotics in the treatment of CPID from the database inception to October 2020.Two investigators independently screened research articles according to inclusion and exclusion criteria and extracted data.Cochrane Handbook for Systematic Reviews of Interventions was used for quality evaluation and RevMan 5.3 software for data analysis.Results:Forty-four RCTs were included，involving 5 143 patients.In the treatment of CPID，Kangfu Xiaoyan Suppository combined with antibiotics was superior to antibiotics alone in improving total effective rate(RR=4.84，95%CI 3.99 to 5.86，P<0.000 01) and shortening the duration of abdominal pain(MD=-2.61，95%CI -3.12 to -2.10，P<0.000 01)，the duration of abdominal distention(MD=-2.54，95%CI -3.22 to -1.85，P<0.000 01)，and the duration of abnormal leukorrhea(MD=-2.82，95%CI -3.26 to -2.39，P<0.000 01).Kangfu Xiaoyan Suppository combined with antibiotics could reduce the incidence of adverse reactions(RR=0.67，95%CI 0.49 to 0.92，P=0.01＜0.05).Conclusion:Based on the existing clinical evidence，the efficacy of Kangfu Xiaoyan Suppository combined with antibiotics against CPID was superior to that of antibiotics alone. |
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