| 引用本文:肖隆灏1,2,3，周昆3，文妍4，刘雨晴3，杜佳颖3，杨兆钢1,2.针刺联合脉络舒通丸治疗脑梗死后假性延髓麻痹吞咽障碍的回顾性分析[J].世界中医药,2022,(22):. |
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| 针刺联合脉络舒通丸治疗脑梗死后假性延髓麻痹吞咽障碍的回顾性分析 |
| Treatment of Pseudobulbar Palsy Dysphagia after Cerebral Infarction with Mailuo Shutong Pills and Acupuncture：A Retrospective Analysis |
| 投稿时间：2022-05-30 |
| DOI：10.3969/j.issn.1673-7202.2022.22.016 |
| 中文关键词: 脉络舒通丸 脑梗死 假性延髓麻痹 吞咽障碍 针刺 通关利窍 回顾性分析 |
| English Keywords:Mailuo Shutong Pills Cerebral infarction Pseudobulbar palsy Dysphagia Acupuncture Tongguan Liqiao Retrospective analysis |
| 基金项目:国家自然科学基金面上项目(81673826)；天津市卫生局中西医结合课题(2019134) |
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| 中文摘要: |
| 目的：探讨脉络舒通丸联合针刺治疗脑梗死后假性延髓麻痹吞咽障碍的临床疗效和安全性。方法：回顾性收集2018年11月至2021年10月在天津中医药大学第一附属医院西医诊断为假性延髓麻痹，中医诊断为中风病的患者186例作为研究对象，根据是否服用脉络舒通丸分为观察组（n=113）和对照组（n=73）。2组患者一般资料比较，差异无统计学意义(P>0.05)。观察组采用脉络舒通丸+针刺+常规治疗，对照组采用针刺+常规治疗，对2组患者治疗前后洼田饮水试验(WST)评级、改良曼恩吞咽能力评估量表(MMASA)评分及其吞咽障碍高相关性子项目评分、吞咽生命质量量表(SWAL-QOL)评分的变化情况进行统计分析。结果：观察组治疗有效率及随访有效率分别为90.27%、92.92%，对照组为76.71%、80.82%，2组比较差异均有统计学意义(均P<0.05)。治疗后，2组患者WST评分、MMASA评分和SWAL-QOL评分比较，差异均有统计学意义(均P<0.05)。治疗后吞咽障碍高相关性子项目评分比较，观察组患者舌肌运动、唾液控制评分优于对照组，2组比较差异均有统计学意义(均P<0.05)。2组均未发生严重不良反应，2组不良反应发生率比较，差异无统计学意义(P>0.05)。结论：脉络舒通丸联合针刺治疗假性延髓麻痹吞咽障碍的临床疗效好于对照组，提示脉络舒通丸可有效改善患者吞咽功能，且具有较高的安全性。 |
| English Summary: |
| To investigate the clinical efficacy and safety of the combination of Mailuo Shutong Pills and acupuncture in the treatment of pseudobulbar palsy dysphagia after cerebral infarction.Methods:A total of 186 patients who were diagnosed with pseudobulbar palsy in western medicine and apoplexy in Chinese medicine at the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from November 2018 to October 2021 were included and were classified into the observation group(n=113，Mailuo Shutong Pills+acupuncture+conventional treatment) and the control group(n=73，acupuncture+conventional treatment) according to the administration of Mailuo Shutong Pills.The pre-treatment and post-treatment water swallow test(WST) grade，Modified Mann Assessment of Swallowing Ability(MMASA) score，score of dysphagia-related items，and Swallowing Quality-of-Life(SWAL-QOL) score were recorded and analyzed.Results:There was no significant difference in the basic data between the two groups(P>0.05).The treatment and follow-up rates of the observation group were 90.27%(102/113) and 92.92%(105/113)，respectively，which were better than those of the control group[76.71%(56/73) and 80.82%(59/73)，separately](P<0.05).After treatment and during follow-up，WST grade，MMASA score，and SWAL-QOL score were higher than those before treatment in the two groups(P<0.05) and higher in the observation group than in the control group(P<0.05).After treatment，the observation group was superior to the control group in tongue muscle movement and saliva control(P<0.05).No serious adverse reactions occurred in either group and the incidence of adverse reactions showed no significant difference between the two groups(P>0.05).Conclusion:The combination of Mailuo Shutong Pills and acupuncture is superior to the control group in the treatment of pseudobulbar palsy dysphagia and the pills can effectively improve the swallowing function of patients and are safe. |
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