To investigate the efficacy of Tongdu Xingnao acupuncture(TXA) combined with aerobic exercise in the treatment of children with cerebral palsy and the effect on serum levels of brain-derived neurotrophic factor(BDNF) and neuron-specific enolase(NSE).Methods:A total of 96 children with cerebral palsy who were treated in Department of Child Rehabilitation,Hebei Hospital of Traditional Chinese Medicine were randomized into control group(n=48) and treatment group(n=48) with the random number table method.The clinical efficacy,Peabody Developmental Motor Scale-2(PDMS-2) score,Gross Motor Function Measure(GMFM) score,Pediatric Quality of Life Inventory(PedsQL) score,TCM syndrome score,and serum levels of BDNF and NSE were compared.Results:After treatment,the total effective rate in treatment group was higher than that in the control group(P<0.05).Before treatment,TCM syndrome scores showed no significant difference between the two groups(P>0.05).After treatment,the major symptom score,minor symptom score,and total TCM syndrome score in two groups were lower than those before treatment(P<0.05),and were lower the treatment group than in the control group(P<0.05).PDMS-2 score,GMFM score,and PedSQL score demonstrated no significant difference between the two groups before treatment(P>0.05).After treatment,the PDMS-2 score,GMFM score,and PedSQL score in two groups were higher than those before treatment(P<0.05),and the scores were higher in the treatment group than in the control group(P<0.05).Serum levels of BDNF and NSE showed no significant difference between the two groups before treatment(P>0.05).After treatment,serum NSE level was significantly decreased,while the serum BDNF level was significantly increased in the two groups(P<0.05).Moreover,serum NSE level was lower and serum BDNF level was higher in the treatment group than in the control group after treatment(P<0.05).Conclusion:The combination of TXA and aerobic exercise can improve the levels of serum BDNF and NSE and clinical efficacy in the treatment of children with cerebral palsy.