| 引用本文:徐亭亭，黄茂，张珊，赵莹，王超.通督醒脑针法联合有氧康复运动治疗小儿脑瘫的疗效研究[J].世界中医药,2022,(22):. |
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| 通督醒脑针法联合有氧康复运动治疗小儿脑瘫的疗效研究 |
| Effect of Tongdu Xingnao Acupuncture Combined with Aerobic Exercise on Infantile Cerebral Palsy |
| 投稿时间：2021-09-27 |
| DOI：10.3969/j.issn.1673-7202.2022.22.017 |
| 中文关键词: 通督醒脑针法 有氧康复运动 小儿脑瘫 临床疗效 血清脑源性神经营养因子、神经元烯醇化酶 中医证候积分 临床疗效 |
| English Keywords:Tongdu Xingnao acupuncture Aerobic exercise Pediatric cerebral palsy Clinical effect Serum levels of BDNF and NSE TCM syndrome score Clinical efficacy |
| 基金项目:河北省中医药管理局科研计划项目（2019056——早期综合康复方案对脑瘫患儿功能障碍影响临床研究；河北省重点研发计划项目（20377786D）——中医针刺疗法结合游戏训练对脑瘫患儿脑功能代偿的研究 |
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| 中文摘要: |
| 目的：探讨通督醒脑针法联合有氧康复运动治疗小儿脑瘫的疗效及对血清脑源性神经营养因子（BDNF）、神经元烯醇化酶（NSE）水平的影响。方法：选取河北省中医院儿童康复科收治的脑瘫患儿96例作为研究对象，按照随机数字表法分为对照组和观察组，每组48例。对照组给予有氧康复运动干预治疗，观察神经元烯醇化酶组采用通督醒脑针法联合有氧康复运动治疗。比较2组治疗后的临床疗效、皮博迪运动发育量表-2（PDMS-2）评分、大肌肉运动技能测量（GMFM）量表评分和小儿生命质量评价量表（PedsQL）评分、中医证候积分、血清BDNF、NSE水平。结果：治疗后，观察组总有效率高于对照组（P<0.05）；治疗前，2组中医证候评分比较差异均无统计学意义（均P>0.05）；治疗后，2组主症评分、次症评分和中医证候总评分均明显降低（均P<0.05）；并且观察组低于对照组（P<0.05）；治疗前2组PDMS-2评分、GMFM评分和PedsQL评分比较，差异均无统计学意义（均P>0.05）；治疗后2组PDMS-2评分、GMFM评分和PedsQL评分均明显升高（均P<0.05）；并且观察组PDMS-2评分、GMFM评分和PedsQL评分均均高于对照组（P<0.05）；治疗前2组血清BDNF、NSE水平比较，差异均无统计学意义（均P>0.05）；治疗后2组血清NSE水平均明显降低，血清BDNF水平均明显升高（均P<0.05）；并且观察组BDNF、NSE水平均优于对照组（均P<0.05）。结论：采用通督醒脑针法联合有氧康复运动治疗小儿脑瘫可更好地改善血清BDNF、NSE水平，提高临床疗效。 |
| English Summary: |
| To investigate the efficacy of Tongdu Xingnao acupuncture(TXA) combined with aerobic exercise in the treatment of children with cerebral palsy and the effect on serum levels of brain-derived neurotrophic factor(BDNF) and neuron-specific enolase(NSE).Methods:A total of 96 children with cerebral palsy who were treated in Department of Child Rehabilitation，Hebei Hospital of Traditional Chinese Medicine were randomized into control group(n=48) and treatment group(n=48) with the random number table method.The clinical efficacy，Peabody Developmental Motor Scale-2(PDMS-2) score，Gross Motor Function Measure(GMFM) score，Pediatric Quality of Life Inventory(PedsQL) score，TCM syndrome score，and serum levels of BDNF and NSE were compared.Results:After treatment，the total effective rate in treatment group was higher than that in the control group(P<0.05).Before treatment，TCM syndrome scores showed no significant difference between the two groups(P>0.05).After treatment，the major symptom score，minor symptom score，and total TCM syndrome score in two groups were lower than those before treatment(P<0.05)，and were lower the treatment group than in the control group(P<0.05).PDMS-2 score，GMFM score，and PedSQL score demonstrated no significant difference between the two groups before treatment(P>0.05).After treatment，the PDMS-2 score，GMFM score，and PedSQL score in two groups were higher than those before treatment(P<0.05)，and the scores were higher in the treatment group than in the control group(P<0.05).Serum levels of BDNF and NSE showed no significant difference between the two groups before treatment(P>0.05).After treatment，serum NSE level was significantly decreased，while the serum BDNF level was significantly increased in the two groups(P<0.05).Moreover，serum NSE level was lower and serum BDNF level was higher in the treatment group than in the control group after treatment(P<0.05).Conclusion:The combination of TXA and aerobic exercise can improve the levels of serum BDNF and NSE and clinical efficacy in the treatment of children with cerebral palsy. |
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