To explore the real-world characteristics of Danshen Ligustrazine Injection in the treatment of elderly patients to provide references for its clinical application and prospective research.Methods:The data of 12 888 elderly patients treated with Danshen Ligustrazine Injection in 23 Grade-A tertiary hospitals in China were collected.The basic data description method，Apriori algorithm for modeling，and Clementine 12.0 for analysis were used.Results:Among the elderly patients enrolled，male patients accounted for 60.33%，while female patients for 39.67%.They were mainly aged 65～75 years(49.73%).The top 3 diseases included hypertension(15.66%)，coronary atherosclerotic heart disease(14.19%)，and malignant tumors(9.78%).The single dose mostly exceeded 10 mL(88.88%).The course of medication was dominated by 1～3 d(71.70%).Among Chinese medicines used for combination，Bianmishu Capsules ranked first in terms of use of frequency(1 582 cases，12.27%)，and among western medicines，potassium chloride sustained release tablets ranked first(4 375 cases，33.95%).In Chinese medicines，blood-activating and stasis-resolving agents(7 406，57.46%)，heat-clearing and toxin-removing agents(2 486，19.29%)，and exterior-releasing agents(2 051，15.91%) were mainly combined.In western medicines，antibiotics(8 315，64.5%)，anticoagulants，thrombolytics and antiplatelet drugs(8 123，63.03%)，and vitamins(6 988，54.22%) were mainly combined.As revealed by the association analysis of Danshen Ligustrazine Injection combined with multiple drugs，the common pair of Chinese medicines for the combination was Fufang Gancao+Bianmishu Capsules，with the support degree of 2.84%，and the common pair of western medicines was vitamin+potassium chloride sustained release tablets，with the support degree of 18.8%.Conclusion:The application of Danshen Ligustrazine Injection in elderly patients conforms to the medication guidelines，and the main diseases for treatment and methods of use are in accordance with the guidelines.As elderly patients are characterized by weakened constitutions，declining digestive system functions，and increased risks of cardiovascular and cerebrovascular diseases and infection，Danshen Ligustrazine Injection is often used in combination with blood-activating and stasis-resolving agents and purgative in TCM and antibiotics and vitamins in western medicine.