Assisted reproductive technology(ART) is a big hope for the older infertile women.However，the clinical outcomes are unsatisfactory because of the poor ovarian reserve，low antral follicle count，low quality of oocytes，and small number of high-quality embryos.Oocyte quality is the key to the pregnancy.Oxidative stress is the main reason for granulosa cell apoptosis and poor oocyte quality.Kidney-tonifying Chinese medicine plays an essential part by alleviating oxidative stress damage，inhibiting granulosa cell apoptosis，improving egg quality，and improving pregnancy rate.Kidney-tonifying Chinese medicine has been widely used in different stages in in vitro fertilization-embryo transfer(IVF-ET).It is a new way for the treatment of older infertile women.