Shengjiang Powder is a famous prescription in traditional Chinese medicine(TCM) for ascending and descending qi movement and dispelling stagnation and heat.In modern clinical practice，Shengjiang Powder or its modified prescription，with or without the combination with western medicine，is used for the treatment of multiple diseases in various systems，including respiratory，digestive，circulation，urinary，nerve，endocrine，and skin diseases.From the evidence-based perspective，this article systematically summarized and reviewed the research on the clinical application of Shengjiang Powder in the past ten years to provide references for the evaluation of the efficacy and rational medication of the prescription.