| 引用本文:伍紫炫1，2，蔡旻捷1，2，黄培冬3，陈嘉韵1，2，吕朝晖2，黄栩研1.抑郁与中医体质相关性的Meta分析[J].世界中医药,2022,(23):. |
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| 抑郁与中医体质相关性的Meta分析 |
| Correlation Between Depression and Traditional Chinese Medicine Constitution：A Meta-analysis |
| 投稿时间：2020-06-29 |
| DOI：10.3969/j.issn.1673-7202.2022.23.016 |
| 中文关键词: 抑郁 中医体质类型 系统评价 Meta分析 气郁质 气虚质 阳虚质 阴虚质 |
| English Keywords:Depression Traditional Chinese medicine constitution types System evaluation Meta-analysis Qi depression Qi deficiency Yang deficiency Yin deficiency |
| 基金项目:云南省卫生健康委2020年高层次中医药后备人才项目（云卫中医发展发〔2021〕1号）；云南省科技厅中医专项面上项目（202001AZ070001-021）——基于PFC-AMG-NAc神经环路可塑性的针刺抗抑郁机制研究；云南省高校针灸防治神志病科技创新团队（2019YGC04） |
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| 中文摘要: |
| 目的：通过Meta分析研究抑郁中医体质类型的分布情况，为抑郁的中医药防治提供更高级别的循证医学证据。方法：检索国家知识基础设施数据库（CNKI）、中国生物医学文献数据库（CBM）、中国学术期刊数据库（CSPD）及中文科技期刊数据库（CCD）、Medline、Embase、The Cochrane Library，纳入符合要求的抑郁与中医体质类型的相关性病例对照文献，提取原始文献资料并评价研究的质量。用Revman 5.3将所纳入的抑郁中医体质类型的病例对照研究进行异质性检验，并以95%置信区间表达效应值。结果：共纳入20项病例对照研究，抑郁患者总计4 612例，非抑郁患者总计7 614例。分布频率气郁质（22.87%)＞气虚质(22.06%)＞阳虚质(17.42%)＞阴虚质(13.25%)。其他5种体质在抑郁人群的分布及占有率差异无统计学意义。所纳入的20项研究中6项中风后抑郁与2项糖尿病后抑郁病例对照研究的方法学质量相对较高，8项单纯抑郁病与4项其他疾病后抑郁的方法学质量较低，总体存在一定的偏倚风险。结论：抑郁发生、发展与气郁和气虚体质的关系最为密切，而阳虚与阴虚体质关系程度略小。纳入原始文献数量和质量所限，存在一定的偏倚风险，有待进一步深入研究。 |
| English Summary: |
| To explore the distribution of traditional Chinese medicine(TCM) constitutions in depression through meta-analysis，to provide a high level of evidence-based medical evidence for the prevention and treatment of depression by TCM.Methods:China National Knowledge Infrastructure(CNKI)，Chinese Biomedical Database(CBM)，China Science Periodical Database(CSPD)，Chinese Citation Database(CCD)，MEDLINE，Embase，and The Cochrane Library were searched to screen qualified case-control literature on the correlation between depression and TCM constitutions.The literature data were extracted to evaluate the quality of the studies.The included case-control studies involving the TCM constitution types in depression was analyzed with Revman 5.3 for heterogeneity test，and the effect size was expressed by 95% confidence interval.Results:A total of 20 case-control studies were included，with 4 612 depressed patients and 7 614 non-depressed patients.In terms of the distribution frequency of TCM constitutions，qi depression(22.87%)>qi deficiency(22.06%)>yang deficiency(17.42%)>yin deficiency(13.25%).There were no differences in the distribution of the other five TCM constitutions among depressed patients.Of the 20 included studies，6 on poststroke depression and 2 on depression after diabetes had high quality in methodology，while 8 on single depression and 4 on depression after other diseases had low quality.Overall，there were certain risks of bias.Conclusion:The occurrence and development of depression are most closely related to qi depression and qi deficiency constitutions，followed by yang deficiency and yin deficiency constitutions.Due to the limited quantity and quality of the original literature，the above conclusions may be biased to some extent，which needs further in-depth study. |
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