世界中医药
文章摘要
引用本文:陈嘉琪1,裴珍珍1,郑粲1,王革生2.基于数据挖掘的从瘀论治脑外伤后综合征组方用药规律分析[J].世界中医药,2022,(23):.  
基于数据挖掘的从瘀论治脑外伤后综合征组方用药规律分析
Medication Law of Traditional Chinese Medicine for Post-traumatic Brain Syndrome(PTBS) from Blood Stasis Based on Data Mining
投稿时间:2020-12-08  
DOI:10.3969/j.issn.1673-7202.2022.23.021
中文关键词:  脑外伤后综合征  中药    数据挖掘  用药规律  关联度分析  聚类分析  因子分析
English Keywords:Post-traumatic brain syndrome(PTBS)  Traditional Chinese medicine  Blood stasis  Data mining  Medication law  Relevance analysis  Cluster analysis  Factor analysis
基金项目:国家中医药管理局国家中医临床基地业务建设科研专项(JDZX2015043);北京中医药大学基本科研业务重点攻关项目(2020-JYB-ZDGG-129)
作者单位
陈嘉琪1,裴珍珍1,郑粲1,王革生2 1 北京中医药大学北京100029 2 北京中医药大学东方医院北京100078 
摘要点击次数: 536
全文下载次数: 0
中文摘要:
      目的:使用数据挖掘的方法探讨从瘀论治脑外伤后综合征的用药规律。方法:检索中国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)、中国学术期刊数据库(CSPD)及中文科技期刊数据库(CCD)获得相关文献并建立数据库,采用频数统计、关联规则、聚类分析、因子分析等数据挖掘技术对核心药物、药对(组)规律进行分析。结果:纳入分析的中医药治疗脑外伤后综合征文献共118篇,涉及128份处方与184味中药,药物出现频次累计2 025次,使用频次前10位的中药是当归、川芎、赤芍、黄芪、桃仁、红花、半夏、甘草、天麻、石菖蒲;药性以“温”为主,五味中以“甘”为主,且归肝经的中药较多。关联规则分析得到21个支持度较高的中药组合,“桃仁-红花”为核心药对。系统聚类分析共得到5个聚类,因子分析得到8个公因子。结论:中医药治疗脑外伤后综合征用药规律以活血化瘀药为主,辅助以理气药、补虚药、安神药等,药物间关联多以桃红四物汤的组方为核心,着重选择药性偏温,味辛甘并归肝经的中药。
English Summary:
      Data mining was used to elucidate the medication law of traditional Chinese medicine(TCM) for post-traumatic brain syndrome(PTBS) from the perspective of blood stasis.Methods:We searched relevant articles from China National Knowledge Infrastructure(CNKI),China Biology Medicine(CBM),China Science Periodical Database(CSPD),and Chinese Citation Database(CCD) to obtain relevant data and a database was established.Then data mining techniques such as frequency count,association rules analysis,cluster analysis,and factor analysis were used to analyze the core medicinals and medicinal pairs(groups).Results:A total of 118 articles on the TCM treatment of PTBS were included,involving 128 prescriptions and 184 medicinals.The cumulative frequency of the medicinals was 2 025,and the top 10 frequently used medicinals were Radix Angelicae Sinensis,Rhizoma Ligustici Chuanxiong,Radix Paeoniae Rubra,Radix Astragali seu Hedysari,Semen Persicae,Flos Carthami,Rhizoma Pinelliae,Radix Glycyrrhizae,Rhizoma Gastrodiae,and Rhizoma Acori Tatarinowii.Particularly,the majority of medicinals were “warm” in property and “sweet” in taste,with liver tropism.Association rules analysis yielded 21 medicinal combinations with high support and the core medicinal pair was “Semen Persicae-Flos Carthami”.Cluster analysis classified the medicinals into 5 clades and factor analysis resulted in 8 common factors.Conclusion:In the TCM treatment of PTBS,blood-activating and stasis-resolving medicinals are mainly used,which are supplemented by qi-regulating medicinals,tonic medicinals,tranquillizing medicinals,etc.The association rules analysis suggests that the core formula is Taohong Siwu Decoction.In addition,meidicinals with warm property,sweet taste,and liver tropism are mainly used.
查看全文  查看/发表评论  下载PDF阅读器