Schisandra lignans are the main active substances of Fructus Schisandrae Chinensis，which have a wide range of pharmacological effects，especially in the treatment of neuropsychiatric diseases.In recent years，massive research on neuropsychiatric diseases have been conducted.Schisandra lignans exert effects in the treatment of Alzheimer's disease，depression，anxiety and other diseases by regulating neurotransmitters，anti-oxidative stress，inhibiting neuroinflammatory response and inhibiting cell apoptosis.Cytochrome P450 and drug transporters play a key role in the biotransformation and metabolic clearance of Schisandra lignans.In clinical practice，drugs containing Schisandra lignans are usually combined with other drugs to treat diseases，and in drug combination，drug interactions based on drug-metabolizing enzymes and mediated by transporters may occur.This article summarized the molecular mechanism of Schisandra lignans in the treatment of neuropsychiatric diseases and the drug interactions，providing a foundation for further experimental research and clinical application of Schisandra lignans.