| 引用本文:耿文倩1，祁烁2，商建伟1，袁姣姣1，张旭帆1，丁治国2.清肝散结消瘿方联合硒制剂治疗桥本甲状腺炎的临床疗效[J].世界中医药,2022,(24):. |
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| 清肝散结消瘿方联合硒制剂治疗桥本甲状腺炎的临床疗效 |
| Clinical Efficacy of Qinggan Sanjie Xiaoying Formula Combined with Selenium in the Treatment of Hashimoto′s Disease |
| 投稿时间：2022-02-16 |
| DOI：10.3969/j.issn.1673-7202.2022.24.019 |
| 中文关键词: 桥本甲状腺炎 清肝散结消瘿方 硒 甲状腺抗体 中医证候 临床研究 疗效 |
| English Keywords:Hashimoto′s disease Qinggan Sanjie Xiaoying Formula Selenium Thyroid antibody TCM syndrome Clinical research Curative effect |
| 基金项目:北京市中医管理局北京中医药“薪火传承3+3工程”建设项目（2016-SZ-C-61）；陕西省中医药管理局2021-2022年度科研项目（2021-GJ-LC001） |
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| 中文摘要: |
| 目的：通过观察清肝散结消瘿方联合硒制剂治疗甲状腺功能正常的桥本甲状腺炎的临床疗效，为其治疗有效性提供依据。方法：采用回顾性研究方法，选取2021年1月1日至2021年10月31日于北京中医药大学孙思邈医院甲状腺病科门诊就诊，至少进行3个月完整治疗的、临床资料齐全的甲状腺功能正常的桥本甲状腺炎患者118例作为研究对象，根据治疗方法不同，分为对照组（n=40）、中药组（n=40）和联合用药组（中药+硒制剂）（n=38）。主要观察指标为甲状腺相关自身抗体和甲状腺功能，次要观察指标为中医证候积分、甲状腺疾病症状群及下肢局部症状的变化情况。结果：治疗后，中药组、联合用药组甲状腺过氧化物酶自身抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）、中医证候积分、汉密尔顿焦虑量表（HAMA）评分、匹兹堡睡眠质量指数（PSQI）、疲劳严重程度量表（FSS）、下肢淋巴水肿自感症状评分均显著下降，差异均有统计学意义（均P<0.05），且均显著低于对照组（均P<0.05）；治疗后，中药组与联合用药组比较，TPOAb、TGAb变化差异均无统计学意义（均P>0.05）。结论：清肝散结消瘿方联合硒制剂治疗桥本甲状腺炎能够有效降低患者的甲状腺自身抗体滴度、改善患者的临床症状。 |
| English Summary: |
| To observe the clinical efficacy of Qinggan Sanjie Xiaoying Formula combined with selenium in the treatment of Hashimoto′s disease with normal thyroid function and provide evidence for the effectiveness of the treatment.Methods:A total of 118 Hashimoto′s disease patients with normal thyroid function admitted to the Thyroid Disease Department of Sunsimiao Hospital of Beijing University of Chinese Medicine from January 1，2021，to October 31，2021，underlying complete treatment for at least three months with complete clinical data were retrospectively included and divided into a control group(n=40)，a traditional Chinese medicine(TCM) group(n=40)，and a combined treatment group(TCM+selenium，n=38).The primary outcome indicators were thyroid-related autoantibodies and thyroid function，and the secondary outcome indicators included TCM syndrome score，thyroid disease symptom group，and changes in local symptoms of lower limbs.Results:After treatment，TPOAb，TGAb，TCM syndrome scores，HAMA scores，PSQI scores，FSS scores，and self-rating scores of lower limb lymphedema in the TCM group and the combined treatment group significantly decreased(all P<0.05)，and they were lower than those in the control group(all P<0.05).After treatment，there was no significant difference in TPOAb and TGAb between the TCM group and the combined treatment group(all P>0.05).Conclusion:Qinggan Sanjie Xiaoying Formula combined with selenium can effectively reduce the titer of thyroid autoantibodies and improve the clinical symptoms of patients with Hashimoto′s disease. |
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