| 引用本文:龚晓薇，蔡建新，徐和祥，柳祥坤，郑婷，王学书.小儿宝泰康颗粒对“风热乘脾证”疱疹性咽峡炎患儿炎症介质及心肌酶谱的影响[J].世界中医药,2022,(24):. |
|
| 小儿宝泰康颗粒对“风热乘脾证”疱疹性咽峡炎患儿炎症介质及心肌酶谱的影响 |
| Effects of Xiaoer Baotaikang Granules on Inflammatory Factors and Myocardial Enzyme Spectrum of Herpangina Children with Wind-heat Attacking Spleen Syndrome |
| 投稿时间：2022-07-11 |
| DOI：10.3969/j.issn.1673-7202.2022.24.020 |
| 中文关键词: 小儿宝泰康颗粒 儿童 疱疹性咽峡炎 风热乘脾证 炎症介质 心肌酶谱 临床试验 中西医 |
| English Keywords:Xiaoer Baotaikang Granules Children Herpangina Wind-heat attacking spleen syndrome Inflammatory factors Myocardial enzyme spectrum Clinical trial Traditional Chinese and western medicine |
| 基金项目:湖北省卫生健康委员会中医药科研项目（ZY2021Z008） |
|
| 摘要点击次数: 138 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：探讨小儿宝泰康颗粒治疗儿童风热乘脾证疱疹性咽峡炎的有效性及作用机制。方法：运用随机对照的临床研究方法，选取2021年1月至2022年1月在武汉市中医医院儿科诊治的风热乘脾证疱疹性咽峡炎患儿64例作为研究对象，随机分为观察组和对照组，每组32例，对照组予以基础治疗，观察组加用小儿宝泰康颗粒口服治疗，疗程为5 d。观察并对比患儿退热时间、咽痛缓解时间、疱疹消退时间、食量恢复时间，同时对炎症介质白细胞介素-6（IL-6）、血清淀粉样蛋白A（SAA）及心肌受损指标肌酸激酶同工酶（CK-MB）等实验室指标进行统计学分析。结果：观察组总有效率96.88%，对照组总有效率84.38%，观察组明显优于对照组（P<0.01）；观察组退热时间、咽痛缓解时间、疱疹消退时间、食量恢复时间比对照组短（P<0.01）；治疗后，2组IL-6、SAA及CK-MB水平较治疗前均降低，且观察组各项水平均低于对照组（P<0.05）。结论：小儿宝泰康颗粒治疗以发热为主诉的风热乘脾证儿童疱疹性咽峡炎可以明显缩短患儿发热时间，缓解疼痛及食欲减退的症状，促进疱疹愈合，同时减轻心肌损害，临床疗效确切，无明显不良反应，其作用机制可能与降低炎症介质从而抑制炎症反应相关，同时可防治心肌受损。 |
| English Summary: |
| To explore the efficacy and mechanism of Xiaoer Baotaikang Granules in the treatment of herpangina with wind-heat attacking spleen syndrome in children.Methods:The randomized controlled trial(RCT) was performed.Sixty-four herpangina children with wind-heat attacking spleen syndrome treated in the Pediatrics Department，Wuhan Hospital of Traditional Chinese Medicine from January 2021 to January 2022 were enrolled and randomly divided into a control group(n=32) and an observation group(n=32).All children underwent conventional treatment，while those in the observation group received additional oral Xiaoer Baotaikang Granules.In both groups，treatment lasted five days.The antipyretic time，pharyngeal pain relief time，herpes resolution time，and food intake recovery time of the two groups were recorded and compared.At the same time，the inflammatory factors interleukin-6(IL-6)，serum amyloid A(SAA)，and myocardial damage index creatine kinase-MB(CK-MB) were statistically analyzed.Results:The total effective rate of the observation group was 96.88%，higher than 84.38% of the control group(P<0.01).The antipyretic time，pharyngeal pain relief time，herpes resolution time，and food intake recovery time of the observation group were shorter than those of the control group(P<0.01).After treatment，the levels of IL-6，SAA，and CK-MB in the two groups were lower than those before treatment，and the levels in the observation group were all lower than those of the control group(P<0.05).Conclusion:Xiaoer Baotaikang Granules in the treatment of herpangina children with wind-heat attacking spleen syndrome characterized by fever can significantly shorten the antipyretic time，relieve the symptoms of pain and loss of appetite，promote the healing of herpes，and reduce myocardial damage，with definite clinical efficacy and no obvious adverse reactions.The underlying mechanism may be mainly related to the reduction of inflammatory factors，thereby inhibiting the inflammatory response，and at the same time，preventing myocardial damage. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
