| 引用本文:马琳1，2，王彧1，2，3，刘陶1，2，赵鑫1，2，陈璐1，2.中医药治疗溃疡性结肠炎的肠道菌群调节机制研究[J].世界中医药,2022,(24):. |
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| 中医药治疗溃疡性结肠炎的肠道菌群调节机制研究 |
| Mechanism of TCM in the Treatment of Ulcerative Colitis by Regulating Gut Microbiota |
| 投稿时间：2021-11-20 |
| DOI：10.3969/j.issn.1673-7202.2022.24.025 |
| 中文关键词: 中医药 肠道菌群 溃疡性结肠炎 免疫调节 菌群代谢物 肠黏膜屏障 粪菌移植 益生菌 |
| English Keywords:traditional Chinese medicine gut microbiota ulcerative colitis immune regulation microbial metabolites intestinal mucosal barrier fecal microbiota transplantation probiotics |
| 基金项目:国家重点研发计划项目（2021YFE0200300）——宣肺败毒方治疗新冠肺炎作用机制的国际合作研究 |
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| 中文摘要: |
| 溃疡性结肠炎（UC）是一种慢性炎症性肠道疾病，以非特异性、易复发和持续性肠道溃疡为特征，被世界卫生组织列为现代难治性疾病之一。研究发现肠道微生态失衡导致肠黏膜屏障（包括免疫屏障、机械屏障和生物屏障）受损导致机体免疫功能障碍，进而参与UC发生发展并导致恶化。中医药治疗UC不仅具有复发率低、不良反应小及作用温和的优势，而且对机体免疫炎症反应和肠道微生态平衡具有正向调节作用。现对中医药通过调节肠道菌群改善免疫紊乱治疗UC的研究现状展开论述，并基于肠道菌群探讨中医药干预措施，为UC的治疗提供新思路。 |
| English Summary: |
| Ulcerative colitis(UC) is a chronic inflammatory bowel disease characterized by non-specificity，easy recurrence，and persistent intestinal ulcers，and it is listed as one of the modern intractable diseases by the World Health Organization.Studies have found that intestinal microecological imbalance leads to damage to the intestinal mucosal barrier(including immune barrier，mechanical barrier，and biological barrier)，triggering immune dysfunction，which in turn is involved in the development and progression of UC.In the treatment of UC，traditional Chinese medicine(TCM) not only has the advantages of low recurrence rate，few side reactions，and mild effects，but also has a positive regulatory effect on the immune inflammatory response and intestinal microecological balance.Therefore，this paper discussed the research progress on TCM in the treatment of UC by regulating gut microbiota to improve immune disorders and explored intervention measures based on the gut microbiota to provide new ideas for the treatment of UC. |
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