| 引用本文:叶青艳1，王见义1，瞿惠燕1，杨涛1，屠燕捷2，郭永洁2，周华1，凌琪华1.基于《中华医典》的泄泻中药内治组方规律研究[J].世界中医药,2023,(01):. |
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| 基于《中华医典》的泄泻中药内治组方规律研究 |
| Formulation Regularity of Prescriptions for Diarrhea in The Chinese Medical Code |
| 投稿时间：2021-03-05 |
| DOI：10.3969/j.issn.1673-7202.2023.01.019 |
| 中文关键词: 泄泻 中药 内治疗法 用药规律 中华医典 数据挖掘 中医传承辅助系统 关联规则 |
| English Keywords:Diarrhea Chinese medicine Internal treatment Medication regularity The Chinese Medical Code Data mining TCMISS Association rules |
| 基金项目:国家科技重大专项（2017ZX10305501-007）；国家自然科学基金项目（81804141）；上海市中医药三年行动计划项目[ZY(2021-2023)-0206-02，ZY(2021-2023)-0101-02）]；国家中医药管理局第六批全国老中医药专家学术经验继承工作项目（IV-1-34） |
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| 中文摘要: |
| 目的：基于中医传承辅助系统软件，分析《中华医典》中治疗泄泻的用药规律，为挖掘中医药治疗泄泻临床及新药研发提供参考。方法：收集《中华医典》中历代治疗泄泻的内服方剂，构建治疗泄泻的古代文献数据库。应用中医传承辅助平台，对筛选出的方剂进行用药频次、四气、五味、归经及组方规律分析。结果：共筛选出治疗泄泻的方剂427首，涉及中药358味。频次≥43次的中药有13味，使用频次较高的前5位药物为：甘草、黄连、干姜、当归、人参，补虚药使用最多，药性主要为温性药，其次为寒性药、平性药，药味主要为苦味，其次为甘味、辛味，主要归脾、胃二经。最常用的药对为干姜-甘草。核心药物组合以黄连、黄柏、阿胶为主的类似处方最多。结论：古代医家治疗泄泻的药味选择上以“寒温并用”为特点，治法以“清补兼施”为主。 |
| English Summary: |
| To explore the medication regularity of prescriptions against diarrhea in The Chinese Medical Code based on Traditional Chinese Medicine Inheritance Support System(TCMISS) to provide new ideas and methods for the clinical treatment of diarrhea by TCM and new drug development.Methods:Oral prescriptions for the treatment of diarrhea in The Chinese Medical Code were collected.A database of ancient literature on the treatment of diarrhea was established.TCMISS was employed to analyze the frequency of drug use，qi，flavor，meridian tropism，and formulation regularity of the screened prescriptions.Results:A total of 427 prescriptions were screened out，involving 358 Chinese herbal drugs.There were 13 Chinese herbal drugs with frequency≥43 times，and the top 5 drugs were Glycyrrhizae Radix et Rhizoma，Coptidis Rhizoma，Zingiberis Rhizoma，Angelicae Sinensis Radix，and Ginseng Radix et Rhizoma.The most commonly used drugs were deficiency-tonifying ones.In terms of drug nature，the majority of drugs were warm，followed by cold and neutral.In terms of flavor，the drugs were mainly bitter，followed by sweet and pungent.The drugs mainly acted on the spleen and stomach meridians.Zingiberis Rhizoma-Glycyrrhizae Radix et Rhizoma served as the most common drug pair.The prescriptions with core combinations of Coptidis Rhizoma，Phellodendri Chinensis Cortex，and Asini Corii Colla were abundant.Conclusion:The medication against diarrhea by ancient doctors is characterized by the combination of cold and warm drugs，and the treatment methods are dominated by both clearing and tonifying. |
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