To study the effect of Tongmai Huazhuo Decoction(THD) on the expression of interleukin-6(IL-6)，interleukin-10(IL-10)，vascular endothelial growth factor(VEGF)，and intercellular adhesion molecule-1(ICAM-1) in rats with coronary heart disease.Methods:A total of 100 SD rats were randomized into control group，model group，and low-dose，medium-dose，and high-dose THD groups by random number table method，with 20 rats in each group.Coronary artery ligation was performed on rats expect the control group to induce coronary heart disease.After modeling，administration began and lasted 4 weeks.The levels of cardiac function indexes，serum IL-6 and IL-10，expression of VEGF and ICAM-1 in myocardium，and serum lipid level were compared among the groups.Results:The left ventricular systolic pressure(LVSP)，maximal rate of rise of left ventricular pressure(+dp/dtmax)，maximal rate of decline of left ventricular pressure(-dop/dtmax)，and levels of IL-10，VEGF，and high-density lipoprotein were lower in the model group and three THD groups than in the control group，and higher in the three THD groups than in the model group.Moreover，the above indexes were higher in the medium-dose and high-dose THD groups than in the low-dose group and higher in the high-dose group than in the medium-dose group(P<0.05).The levels of IL-6，ICAM-1，cholesterol and low-density lipoprotein in the model group and three THD groups were higher than those in the control group，and the levels in the three THD groups were lower than those in the model group.In addition，the levels were lower in the in the medium-dose and high-dose THD groups than in the low-dose group，and lower in the high-dose group than in the medium-dose group(P<0.05).Conclusion:THD can down-regulate the levels of IL-6 and ICAM-1 and up-regulate the levels of IL-10 and VEGF，which explains the efficacy on coronary heart disease.