| 引用本文:阮智超，倪博然，李家木，赵进喜.3种活血化瘀类中成药治疗糖尿病肾病Ⅲ期的系统综述[J].世界中医药,2023,(02):. |
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| 3种活血化瘀类中成药治疗糖尿病肾病Ⅲ期的系统综述 |
| Systematic Review and Meta-Analysis of Three Kinds of Proprietary Chinese Medicines for Activating Blood and Resolving Stasis in the Treatment of Stage Ⅲ Diabetic Nephropathy |
| 投稿时间：2021-10-28 |
| DOI：10.3969/j.issn.1673-7202.2023.02.009 |
| 中文关键词: 尿毒清 肾衰宁 渴洛欣 糖尿病肾病 系统综述 Meta分析 中成药 活血化瘀 |
| English Keywords:Niaoduqing Shenshuaining Keluoxin Diabetic nephropathy Systematic review Meta analysis Proprietary Chinese medicine Activating blood and resolving stasis |
| 基金项目:国家自然科学基金面上项目(8207151004) |
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| 中文摘要: |
| 目的:探讨尿毒清、肾衰宁、渴洛欣3种活血化瘀类中成药治疗糖尿病肾病Ⅲ期的有效性及安全性。方法:计算机检索国家知识基础设施数据库(CNKI)、中国生物医学文献数据库(CBM)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、PubMed、Medline、Cochrane Library、EMbase建库至2020年10月收录的尿毒清、肾衰宁、渴洛欣治疗糖尿病肾病Ⅲ期的随机对照试验文献。应用Cochrane工具对纳入的文献进行偏倚风险评估,采用Revman5.3和stata14.0软件进行分析。结果:共纳入文献17篇,涉及1 225例受试者。Meta分析结果显示:3种活血化瘀类中成药治疗糖尿病肾病Ⅲ期在尿白蛋白排泄率(MD=-21.44,95%CI为-24.70~-18.18,Z=12.88,P<0.000 01)、肌酐(MD=-7.56,95%CI为-9.62~-5.50,Z=7.20,P<0.000 01)、尿素氮(MD=-0.83,95%CI为-1.35~-0.30,Z=3.06,P=0.002)方面优于单纯西医治疗。安全性方面(MD=1.07,95%CI为0.68~1.67,Z=0.28,P=0.78)二者差异无统计学意义。结论:尿毒清、肾衰宁、渴洛欣3种活血化瘀中成药,能够改善糖尿病肾病Ⅲ期患者肾功能,并降低其尿白蛋白排泄率,是安全、有效的辅助治疗药物。 |
| English Summary: |
| To explore the efficacy and safety of three kinds of proprietary Chinese medicines for activating blood and resolving stasis in the treatment of stage Ⅲ diabetic nephropathy.Methods:Randomized controlled trials on the treatment of stage Ⅲ diabetic nephropathy by Naoduqing，Shenshuaining，and Keluoxin were retrieved from CNKI，Wanfang Data，China Biology Medicine(CBM)，China Science Periodical Database(CSPD)，Chinese Citation Database(CCD)，PubMed，Medline，Cochrane Library，and EMbase(from inception to October 2020).Cochrane was used to assess the risk of bias in the included articles，and Revman5.3 and stata14.0 were employed for analysis.Results:A total of 17 articles were included，involving 1 225 cases.The results of Meta analysis showed that the three kinds of proprietary Chinese medicines were superior to western medicine alone in terms of excretion rate of urinary albumin(MD=-21.44，95%CI -24.70 to -18.18，Z=12.88，P<0.000 01)，creatinine(MD=-7.56，95%CI -9.62 to -5.50，Z=7.20，P<0.000 01），and urea nitrogen(MD=-0.83，95%CI -1.35 to -0.30，Z=3.06，P=0.002）.There was no significant difference in safety between the proprietary Chinese medicines and western medicine(MD=1.07,95%CI 0.68 to 1.67，Z=0.28，P=0.78).Conclusion:Naoduqing，Shenshuaining，and Keluoxin can improve the renal function of patients with stage Ⅲ diabetic nephropathy，and reduce the excretion rate of urinary albumin.They are safe and effective adjuvant drugs. |
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