To observe the clinical effect of Shexiang Baoxin Pills combined with recombinant human brain natriuretic peptide on patients with mild to moderate acute myocardial infarction(AMI).Methods:A total of 110 patients with AMI，whose cardiac function Killip grade was Grade Ⅰ or Grade Ⅱ，were selected and divided into a control group and an observation group according to the random number table，with 55 cases in each group.The control group was treated with recombinant human brain natriuretic peptide，and the observation group was treated with Shexiang Baoxin Pills based on the control group.The clinical efficacy，blood lipid levels，and inflammatory factor levels ［high-sensitivity C-reactive protein(hs-CRP)，interleukin-8(IL-8)，and tumor necrosis factor-α(TNF-α)］，cardiac function indexes，vascular endothelial function，vascular recanalization rate，and incidence of bleeding were compared between the two groups before and after treatment.Results:As compared with the control group，the total effective rate of the observation group was higher(P<0.05).As compared with the control group，the blood vessel recanalization rate in the observation group was higher and the bleeding rate was lower(P<0.05).After treatment，the levels of blood lipid，hs-CRP，TNF-α，and IL-8 in the observation group decreased significantly(P<0.05).The levels of left ventricular ejection fraction(LVEF)，left ventricular peak filling rate(LVPFR)，and nitric oxide(NO) in the two groups were higher than those before treatment，while the levels of LVEDD and ET-1 were lower than those before treatment.The levels of LVEF，LVPFR and NO in the observation group were significantly higher than those in the control group，while the levels of left ventricular end diastolic diameter(LVEDD) and endothelin-1(ET-1) were lower(P<0.05).Conclusion:Shexiang Baoxin Pills combined with recombinant human brain natriuretic peptide have a significant effect on the treatment of patients with mild to moderate AMI and have certain clinical application value，which can be further studied and promoted.