To evaluate the clinical effect of acupuncture with the overall selection of points based on the etiology of psychosomatic diseases in The Yellow Emperor's Inner Classic and local acupoints of aromatase inhibitors(AIs) on patients with AI joint pain in the recovery period of breast cancer.Methods:A total of 232 AI patients with breast cancer using zoledronic acid in the First Affiliated Hospital of Nanjing Medical University from January 2019 to May 2021 were included.According to the willingness to acupuncture and moxibustion，35 patients were divided into a treatment group(n=16) and a control group(n=19).The control group received routine analgesia with zoledronic acid，and the treatment group received acupuncture and moxibustion with holistic and local acupoints combined with zoledronic acid for 4 weeks.The Functional Assessment of Cancer Therapy-Breast(FACT-B) and Brief Pain Inventory-Short Form(BPI-SF) were evaluated before treatment，at 2，4，and 8 weeks of treatment，and the safety of acupuncture treatment was also evaluated.Results:FACT-B in the treatment group was higher than that in the control group at 4 and 8 weeks of treatment，and BPI-SF in the treatment group was lower than that in the control group at 4 weeks(P<0.05).Conclusion:The combination of overall and local acupoints has a good clinical effect on the quality of life and local joint symptoms of AI patients in the recovery stage of breast cancer.