To analyze the medication rule of traditional Chinese medicine(TCM) for lupus nephritis based on data mining and thereby to provide a reference for clinical prescription.Methods:The TCM prescriptions for lupus nephritis in articles published in recent 10 years were summarized and input into Traditional Chinese Medicine Inheritance Support System(V3.0).The improved mutual information approach and complex system entropy cluster were employed to analyze the medication rule.Results:A total of 89 prescriptions were screened out.Among the medicinals in the prescriptions，Poria enjoyed the highest frequency.The medicinals were generally cold，warm，or plain in nature and sweet or bitter in taste，with lung or kidney tropism and efficacy of tonifying deficiency and clearing heat.As for the medicinal pairs in the prescription，Poria-Radix Astragali seu Hedysari combination was most popular，and cluster analysis yielded three core combinations.A large proportion of the patients had red tongue，thread pulse，blood stasis syndrome，qi deficiency syndrome and yin deficiency syndrome.Conclusion:Based on the frequently used medicinals，TCM emphasizes reinforcing heathly qi and eliminating pathogen in the treatment of lupus nephritis，with clearing heat and cooling blood，excreting water and eliminating edema，promoting blood circulation and removing stasis as priority and invigorating the spleen and tonifying kidney，replenishing qi and nourishing yin as supplement.