Cerebral ischemia is a condition that occurs suddenly when there isn't enough blood flow to the brain to meet metabolic demand，with high incidence，mortality，and disability rate，threatening human life quality and even life.The pathogenesis of this disease is complex，involving inflammatory response，oxidative stress，and toxicity of excitatory amino acid.The typical qi-replenishing and blood-activating Radix Astragali seu Hedysari-Flos Carthami pair exerts anti-inflammatory，antithrombus，and apoptosis-inhibiting effects in the treatment of cerebral ischemia.However，the mechanism of the pair and their components against cerebral ischemia is rarely studied.