Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest.The incidence has been on the rise，and this disease has brought heavy burden to patients，families，and society.At the moment，antidepressants are mainly used，which，however，have disadvantages，such as side effects，drug dependence and relapse after withdrawal.Acupuncture and moxibustion，as a non-drug therapy，has multi-level，multi-target，and multi-system regulatory effects compared with the western medicine，which can dredge meridian and collateral，stimulate meridian qi，promote the movement of qi and blood，and regulate yin and yang，and significantly improve the symptoms of insomnia，anxiety，and black mood in patients with depression.This study summarized the achievements in experimental research and clinical research on acupuncture and moxibution in the treatment of depression in recent five years and pointed out the limitations，so as to provide a reference for the scientific research and clinical work of acupuncture and moxibustion in the treatment of depression.