| 引用本文:方旭琴1,2，崔向宁1，曲艺1,2，林虹辰1,2，蒋之林1.基于文献的从脾胃论治冠状动脉粥样硬化性心脏病的用药规律研究[J].世界中医药,2023,(05):. |
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| 基于文献的从脾胃论治冠状动脉粥样硬化性心脏病的用药规律研究 |
| Medication Rules of Tradition Chinese Medicine in Treating Coronary Heart Disease from Spleen and Stomach Based on Literature |
| 投稿时间：2021-10-23 |
| DOI：10.3969/j.issn.1673-7202.2023.05.018 |
| 中文关键词: 冠心病 脾胃论治 中药复方 文献研究 中医传承辅助平台 用药规律 关联规则 肠道菌群 |
| English Keywords:Coronary heart disease Treatment from spleen and stomach Chinese medicinal prescriptions Literature research Traditional Chinese Medicine Inheritance Assistance System Medication rules Association rules Gut microbiota |
| 基金项目:国家自然科学基金面上项目(81973842) |
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| 中文摘要: |
| 目的：探讨中医从脾胃治疗冠心病的用药规律，为临床治疗冠心病提供参考。方法：计算机检索国家知识基础设施数据库、中国学术期刊数据库和中文科技期刊数据库中从脾胃论治冠心病的相关文献，录入中医传承辅助平台（V2.5），运用“统计报表”“数据分析”模块进行数据挖掘，分析从脾胃论治冠心病的用药规律。结果：共纳入160首处方，涉及198味药物。数据挖掘分析得出处方中≥30次的高频药物16味，其中前3位分别是茯苓、丹参、陈皮，四气以温、寒、平为主，五味以甘、苦、辛为主，归经以脾胃、肺、心、肝为主，高频药物组合20组，药物关联规则2条，熵聚类分析得到3味药的药物组合14组，新处方7首。结论：从脾胃论治冠心病的组方特点是在益气健脾的同时予以理气化痰、活血化瘀、醒脾开胃、调畅脾胃气机等药物，标本兼顾，可为临床治疗冠心病提供参考。 |
| English Summary: |
| To explore the medication rules of traditional Chinese Medicine(TCM) in treating coronary heart disease from spleen and stomach and provide reference for clinical treatment of this disease.Methods:The relevant articles were retrieved from the China National Knowledge Infrastructure(CNKI)，China Science Periodical Database(CSPD)，and China Science and Technology Journal Database(CSTJ).The retrieved articles were input into the TCM inheritance assistance platform(V2.5).The “statistical report” and the “data analysis” modules were used for data mining，via which the medication rules in treatment of the disease from spleen and stomach were analyzed.Results:A total of 160 prescriptions involving 198 Chinese medicines were input into the platform for the data mining.Sixteen Chinese medicines with the frequency≥30 were mined from the prescriptions，and the top three in frequency were Poria，Salviae Miltiorrhizae Radix et Rhizoma，and Citri Reticulatae Pericarpium.The Chinese medicines were mainly warm，cold，and plain，tasted sweet，bitter，and pungent，and had tropism to the spleen，stomach，lung，heart，and liver meridians.Twenty high-frequency drug combinations and two association rules were obtained.The cluster analysis based on entropy revealed 14 three-drug combinations and 7 new prescriptions.Conclusion:The prescriptions for treating coronary heart disease from spleen and stomach aim to regulate qi and resolve phlegm，active blood and resolve stasis，enliven spleen and improve appetite，and regulate qi in spleen and stomach while replenishing qi and invigorating spleen with consideration to both the symptoms and root causes.The findings can provide reference for the clinical treatment of coronary heart disease. |
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