To reveal the medication rules in the treatment of depressive psychosis and mania by data mining from ancient medical records.Methods:The Ancient and Modern Medical Records Cloud Platform was searched for the medcial records with relevant keywords，and a library of ancient medical records of the treatment of depressive psychosis and mania by famous physicians was built.EXCEL and SPSS were employed to perform frequency statistics，association analysis，and cluster analysis，and Gephi to perform complex network analysis，on the basis of which the medication rules were mined.Results:A total of 223 articles were included in this study，The articles included 283 Chinese medicine prescriptions，which involved 271 Chinese medicines.The high-frequency Chinese medicines were Glycyrrhizae Radix et Rhizoma，Acori Tatarinowii Rhizoma，Poria cum Radix Pini，Ginseng Radix et Rhizoma，Polygalae Radix，Coptidis Rhizoma，and Pinelliae Rhizoma.The association analysis predicted the herb pairs such as Poria cum Radix Pini-Ziziphi Spinosae Semen and Polygalae Radix-Acori Tatarinowii Rhizoma.The cluster analysis revealed Xiaoyao Powder，Wendan Decoction，and Mangshi Guntan Pills.The core prescription was modified Shiwei Wendan Decoction.Conclusion:Ancient physicians focus on phlegm in the treatment of depressive psychosis and mania while differentiating the deficiency and excess.On the basis of syndrome differentiation，the therapies of regulating qi and relieving depression，clearing liver and promoting bile secretion，relaxing bowls and removing excess，tonifying heart and replenishing spleen，nourishing yin and purging fire，and tranquilizing mind with heavy sedatives are employed，which demonstrate good efficacy.