| 引用本文:双荣1，2，其日格尔2，3，乌日汉2，白梅荣2，3，拉喜那木吉拉2，3，韩晓静2，3.蒙药红花水提物的毒性观察[J].世界中医药,2023,(07):. |
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| 蒙药红花水提物的毒性观察 |
| Toxicity of Carthamus tinctorius L.Water Extract |
| 投稿时间：2021-07-22 |
| DOI：10.3969/j.issn.1673-7202.2023.07.014 |
| 中文关键词: 蒙药红花水提物 长期毒性 肝 心 肾 灌胃 用药剂量 组织病理 |
| English Keywords:Carthamus tinctorius L.water extract Long-term toxicity Liver Heart Kidney Intragastric administration Dosage Histopathology |
| 基金项目:内蒙古自治区本科直属高校2019年“双一流”建设专项资金蒙药科研创新团队建设项目（190302）；蒙药安全性评价创新团队项目（MY20190003）；国家民委-教育部蒙医药研发重点实验室开放课题（MDK2019063） |
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| 中文摘要: |
| 目的:血清动态观察蒙药红花水提物（HS）对肝、心、肾的毒性作用。方法:将蒙药红花水提物分为低、中、高剂量组及正常组，分别灌胃3个月HS，每天灌胃1次，每14 d尾部采血1次，动态观察血清谷丙转氨酶（GPT）、谷草转氨酶（GOT）、三酰甘油酯（TG）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、尿素（Urea）、肌酐（Cr）水平的变化；3个月后处死大鼠，取肝、心、肺、肾、脾、胃、肠、脑组织做苏木精-伊红染色（HE）病理观察。结果：HS低、中、高剂量组持续用药3个月后大鼠血清GPT、GOT、TG、LDH、CK、Urea、Cr水平和组织病理切片结果发现对肝、心、肾基本无损伤。结论：根据血清GPT、GOT、TG、CK、LDH、Gr、Urea水平和组织病理学观察发现，服用HS（0.476 7～8.580 6 g/kg）长达3个月对肝、心、肾基本无毒性。 |
| English Summary: |
| To observe the toxicity of the water extract of the Mongolian medicinal herb Carthamus tinctorius L.(HS) to the liver，heart，and kidney.Methods:Rats were intragastrically administrated with low-，medium-，and high-dose HS water extracts once a day for 3 months.Blood was collected from the tail once every 14 days.The serum levels of glutamic-pyruvic transaminase(GPT)，glutamic-oxalacetic transaminase(GOT)，triglycerides(TG)，lactic dehydrogenase(LDH)，creatine kinase(CK)，urea，and creatinine(Cr) were determined.Three months later，the rats were sacrificed and the liver，heart，lung，kidney，spleen，stomach，intestine，and brain were collected.Hematoxylin-eosin(HE) staining was employed for the observation of pathological changes.Results:The serum levels of GPT，GOT，TG，LDH，CK，Urea，and Cr and the tissue sections showed that the three months of treatment with low-，medium-，and high-dose HS water extracts basically did not cause injuries in the liver，heart or kidney.Conclusion:The administration with HS water extract within 0.476 7～8.580 6 g/kg for three months has no toxic or side effect on the liver，heart，and kidney. |
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