| 引用本文:安琪，杜玉青，李友山，杨剑锋，张艳，余清璇，张力睿，刘胜男.拔毒生肌散治疗慢性难愈性创面的系统评价和Meta分析[J].世界中医药,2023,(07):. |
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| 拔毒生肌散治疗慢性难愈性创面的系统评价和Meta分析 |
| Systematic Evaluation and Meta-analysis of Badu Shengji Powder in the Treatment of Chronic Refractory Wounds |
| 投稿时间：2022-11-23 |
| DOI：10.3969/j.issn.1673-7202.2023.07.018 |
| 中文关键词: 拔毒生肌散 慢性难愈性创面 外用 系统评价 Meta分析 随机对照试验 临床疗效 有效率 |
| English Keywords:Badu Shengji Powder Chronic refractory wound External application Systematic evaluation Meta-analysis Randomized controlled trials Clinical curative effect Effective rate |
| 基金项目:国家自然科学基金面上项目（81973849-H2709） |
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| 中文摘要: |
| 目的：探究拔毒生肌散治疗慢性难愈性创面的临床疗效。方法：计算机检索国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库(CBM)、美国医学文献数据库（Medicine）及考克兰图书馆数据库（the Cochrane Library），并通过搜查关键词检索筛选相关文献，搜集拔毒生肌散治疗慢性难愈性创面疗效的临床随机对照试验（RCT），检索时限均从建库至2022年10月。由2名评价者分别按照纳排标准筛选文献、提取资料并评价纳入研究的偏倚风险后，采用RevMan5.3软件进行系统评价和Meta分析。结果：共纳入14篇RCT文献，包括787例患者，其中观察组394例，对照组393例。Meta分析结果显示：观察组创面的愈合率高于对照组（OR=4.08，95%CI为2.55~6.55，P<0.000 01）；观察组创面的有效率高于对照组（OR=6.08，95%CI为3.45~10.73，P<0.000 01）；观察组创面的愈合时间低于对照组（MD=-3.07，95%CI为-4.12~-2.03，P<0.000 01）；观察组的疼痛评分低于对照组（MD=-1.18，95%CI为-2.03~-0.33，P=0.006）。结论：临床应用拔毒生肌散可以提高慢性难愈性创面的愈合率和有效率，并且缩短创面的愈合时间，减轻疼痛。但因纳入研究的局限性，上述结论仍然需要更多高质量研究验证。 |
| English Summary: |
| To explore the clinical efficacy of Badu Shengji Powder in the treatment of chronic refractory wounds.Methods:China National Knowledge Infrastructure(CNKI)，China Science Periodical Database(CSPD)，Chinese Citation Database(CCD)，China Biology Medicine(CBM)，American Medicine Database(Medicine)，and the Cochrane Library were searched for clinical randomized controlled trials(RCTs) on the efficacy of Badu Shengji Powder in treating chronic refractory wounds by keywords from database inception to October 2022.After two investigators screened the literature in accordance with inclusion and exclusion criteria，extracted the data，and evaluated the risk of bias of included studies，RevMan5.3 software was used for systematic evaluation and Meta-analysis.Results:Fourteen RCTs were included，with 787 patients involved，i.e.，394 patients in the treatment group and 393 patients in the control group.Meta-analysis showed that the wound healing rate in the treatment group was higher than that in the control group(OR=4.08，95%CI 2.55 to 6.55，P<0.000 01).The effective rate of wounds in the treatment group was higher than that in the control group(OR=6.08，95%CI 3.45 to 10.73，P<0.000 01).The wound healing time in the treatment group was shorter than that in the control group(MD=-3.07，95%CI -4.12 to -2.03，P<0.000 01).The pain score of the treatment group was lower than that of the control group(MD=-1.18，95%CI -2.03 to -0.33，P＝0.006).Conclusion:The current evidence shows that the clinical application of Badu Shengji Powder can improve the healing rate of chronic refractory wounds and the effective rate，shorten the healing time of wounds，and relieve pain.However，due to the limitations of the studies included，the above conclusion still needs more high-quality research validation. |
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